Table 1. Null Activities of βArr2 Mice.
Genotypea | Treatment conditionb | Mean null activity (mAmp) | SEM |
---|---|---|---|
WT | Veh–Veh | 2.60 | ±0.18 |
Veh–0.2 mg/kg UNC9975 | 2.57 | ±0.39 | |
Veh–0.5 mg/kg UNC9975 | 1.88 | ±0.39 | |
Veh–1 mg/kg UNC9975 | 4.19 | ±0.39 | |
PCP–Vehc | 5.45 | ±0.98 | |
PCP–0.2 mg/kg UNC9975c | 5.97 | ±1.21 | |
PCP–0.5 mg/kg UNC9975c | 4.09 | ±0.46 | |
PCP–1 mg/kg UNC9975c | 6.88 | ±0.75 | |
KO | Veh–Veh | 3.10 | ±0.51 |
Veh–0.2 mg/kg UNC9975 | 2.68 | ±0.41 | |
Veh–0.5 mg/kg UNC9975 | 2.34 | ±0.42 | |
Veh–1 mg/kg UNC9975 | 5.29 | ±0.62 | |
PCP–Vehc | 5.55 | ±0.74 | |
PCP–0.2 mg/kg UNC9975c | 5.33 | ±1.06 | |
PCP–0.5 mg/kg UNC9975c | 4.11 | ±0.46 | |
PCP–1 mg/kg UNC9975c | 9.09 | ±1.46 |
N=9–23 mice/genotype/treatment condition.
A two-way ANOVA for null activity found only the main effect of treatment was significant (F(7, 187)=10.94, p<0.001).
PCP=phencyclidine, 6 mg/kg was given.