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. 2015 Sep 2;41(3):858–868. doi: 10.1038/npp.2015.212

Figure 3.

Figure 3

The effect of GBR-12909 (GBR; n=11) and atomoxetine (ato; n=8) on operant responding for social play behavior. Treatment with GBR-12909 (3–10 mg/kg, s.c.) enhanced responding for social play. GBR-12909 increased the number of rewards obtained (a) and the breakpoint (b). Administration of GBR-12909 did not affect the frequency of pinning (c), or the time spent on social exploration (d). Treatment with atomoxetine (1–3 mg/kg, i.p.) reduced operant responding and social play behavior. The number of rewards obtained was reduced (e) and the breakpoint was lower (f). In addition, the frequency of pinning (g) was reduced. The time spent on social exploration was unaffected (h). Data are presented as mean+SEM. *p<0.05, **p<0.01, ***p<0.001, relative to saline (0 mg/kg GBR/ato) treatment.