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. 1977 Dec;32(6):684–690. doi: 10.1136/thx.32.6.684

Inhibition of aspirin-induced bronchoconstriction by sodium cromoglycate inhalation.

N A Martelli, G Usandivaras
PMCID: PMC470813  PMID: 414371

Abstract

Five patients with asthma and severe aspirin hypersensitivity were challenged on separate days with increasing doses of aspirin given by mouth, starting with 5 mg, until a reduction in FEV1 greater than 15% was obtained. Sodium cromoglycate in doses of 20-40 mg inhibited the bronchoconstrictive reaction not only when inhaled before the challenge but also after it, at a time when progressive reduction in FEV1 values was taking place. According to these results, it seems reasonable to postulate sequential mast cell degranulation and liberation of mediators of anaphylaxis as the mechanism through which aspirin induces bronchoconstriction in aspirin-sensitive asthmatics. The differences between bronchial provocation tests and oral challenge with aspirin are stressed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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