Abstract
Prediction equations have been evolved for the assessment of vital capacity, total lung capacity, and the single breath carbon monoxide transfer factor in haemoglobin SS and haemoglobin SC disease. These relationships take account of the growth disorder and anaemia in the sickle-cell states. The results suggest that, in the clinically stable state, any effects of alveolar capillary sickling and haemoconcentration and any altered reactivity of haemoglobins S and C with the test gas are of no significance for clinical respiratory physiology. Sex differences in lung function appear independent of haemoglobin type.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BLAKEMORE W. S., FORSTER R. E., MORTON J. W., OGILVIE C. M. A standardized breath holding technique for the clinical measurement of the diffusing capacity of the lung for carbon monoxide. J Clin Invest. 1957 Jan;36(1 Pt 1):1–17. doi: 10.1172/JCI103402. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Condon P. I., Serjeant G. R. Ocular findings in hemoglobin SC disease in Jamaica. Am J Ophthalmol. 1972 Nov;74(5):921–931. doi: 10.1016/0002-9394(72)91213-5. [DOI] [PubMed] [Google Scholar]
- JONES N. L., GOODWIN J. F. RESPIRATORY FUNCTION IN PULMONARY THROMBOEMBOLIC DISORDERS. Br Med J. 1965 Apr 24;1(5442):1089–1093. doi: 10.1136/bmj.1.5442.1089. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miller G. J., Serjeant G. R. An assessment of lung volumes and gas transfer in sickle-cell anaemia. Thorax. 1971 May;26(3):309–315. doi: 10.1136/thx.26.3.309. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rodkey F. L., O'Neal J. D., Collison H. A., Uddin D. E. Relative affinity of hemoglobin S and hemoglobin A for carbon monoxide and oxygen. Clin Chem. 1974;20(1):83–84. [PubMed] [Google Scholar]