Abstract
El-Bermani, Al-Walid I. (1978).Thorax, 33, 167-174. Pulmonary noradrenergic innervation of rat and monkey: a comparative study. The noradrenergic innervation of rat and monkey lungs was studied using the fluorescence histochemical method for norepinephrine of Falck (1962). In both species the noradrenergic nerves enter the lung at the hilum in association with the bronchial arteries. Major differences were noted in the distribution and pattern of these nerves, the most important of which are as follows: (1) Noradrenergic nerves have terminal varicosities in all divisions of the rat bronchial artery but are varicose in only the medium and small bronchial arteries of the monkey. (2) Noradrenergic terminals (varicosities) are in direct association with the bronchial smooth muscle in the monkey, but in the rat most of the noradrenergic nerves pass through the smooth muscle layer without forming terminal varicosities. Smooth muscle noradrenergic innervation is seen only at bifurcation points. (3) In the monkey pulmonary artery, noradrenergic terminals are restricted to the adventitio-medial junction while they appear in the media of the rat pulmonary artery. (4) Noradrenergic terminals are present in all pulmonary vein divisions of the monkey whereas in the rat the large pulmonary veins lack noradrenergic nerves.
Both rat and monkey bronchial arteries and pulmonary veins were found to have adrenergic terminal varicosities deep in the medial layer. The rat pulmonary artery also has such medial terminations. In both species there is a preponderance of noradrenergic terminals in the vasa vasorum, and we think that this may be important in regulating the delivery of humoral substances to vascular walls.
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- Altenähr E. Untersuchungen über die Feinstruktur der vegetativen Innervation der Rattenlunge. Z Mikrosk Anat Forsch. 1965;72(4):439–518. [PubMed] [Google Scholar]
- Bennett T. The adrenergic innervation of the pulmonary vasculature, the lung and the thoracic aorta, and on the presence of aortic bodies in the domestic fowl (Gallus gallus domesticus L.). Z Zellforsch Mikrosk Anat. 1971;114(1):117–134. doi: 10.1007/BF00339470. [DOI] [PubMed] [Google Scholar]
- Bradley D. E., McNary W. F., el-Bermani A. W. The distribution of acetylcholinesterase and catecholamine containg nerves in the rat lung. Anat Rec. 1970 Jun;167(2):205–207. doi: 10.1002/ar.1091670208. [DOI] [PubMed] [Google Scholar]
- Cech S. Adrenergic innervation of blood vessels in the lung of some mammals. Acta Anat (Basel) 1969;74(2):169–182. [PubMed] [Google Scholar]
- El-Bermani A. W., Grant M. Acetylcholinesterase-positive nerves of the rhesus monkey bronchial tree. Thorax. 1975 Apr;30(2):162–170. doi: 10.1136/thx.30.2.162. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FUXE K., SEDVALL G. THE DISTRIBUTION OF ADRENERGIC NERVE FIBRES TO THE BLOOD VESSELS IN SKELETAL MUSCLE. Acta Physiol Scand. 1965 May-Jun;64:75–86. doi: 10.1111/j.1748-1716.1965.tb04155.x. [DOI] [PubMed] [Google Scholar]
- Fillenz M. Innervation of pulmonary and bronchial blood vessels of the dog. J Anat. 1970 May;106(Pt 3):449–461. [PMC free article] [PubMed] [Google Scholar]
- Fisher A. W. The intrinsic innervation of the pulmonary vessels. Acta Anat (Basel) 1965;60(4):481–496. doi: 10.1159/000142658. [DOI] [PubMed] [Google Scholar]
- HONJIN R. On the nerve supply of the lung of the mouse, with special reference to the structure of the peripheral vegetative nervous system. J Comp Neurol. 1956 Oct;105(3):587–625. doi: 10.1002/cne.901050308. [DOI] [PubMed] [Google Scholar]
- LOCKETT M. F. The transmitter released by stimulation of the bronchial sympathetic nerves of cats. Br J Pharmacol Chemother. 1957 Mar;12(1):86–96. doi: 10.1111/j.1476-5381.1957.tb01367.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zussman W. V. Fluorescent localization of catecholamine stores in the rat lung. Anat Rec. 1966 Sep;156(1):19–29. doi: 10.1002/ar.1091560105. [DOI] [PubMed] [Google Scholar]