Abstract
In 520 men who currently smoked only cigarettes, carboxyhaemoglobin (COHb) levels were measured as a method of estimating the extent to which cigarette smoke was inhaled and the results were compared with the smokers' own assessment of their inhaling habits. The mean COHb level after standardising for the number of cigarettes smoked before the blood test on the day of the test was 4.0% in self-described non-inhalers. This was much higher than the mean level of 0.7% in 1891 similar non-smokers, but not very different from the standardised mean levels of 5.2%, 5.3%, and 5.6% in men who said they inhaled slightly, moderately, or deeply, respectively. The increasing trend in the COHb levels of men in the four self-described inhaling categories (nil to deep) was small but statistically highly significant. The data from this study may help to explain some of the anomalous epidemiological results regarding the relationship between self-described inhaling habits and the development of diseases associated with smoking, such as coronary heart disease and lung cancer.
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Selected References
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- COMMINS B. T., LAWTHER P. J. A SENSITIVE METHOD FOR THE DETERMINATION OF CARBOXYHAEMOGLOBIN IN A FINGER PRICK SAMPLE OF BLOOD. Br J Ind Med. 1965 Apr;22:139–143. doi: 10.1136/oem.22.2.139. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DOLL R., HILL A. B. A study of the aetiology of carcinoma of the lung. Br Med J. 1952 Dec 13;2(4797):1271–1286. doi: 10.1136/bmj.2.4797.1271. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DOLL R., HILL A. B. MORTALITY IN RELATION TO SMOKING: TEN YEARS' OBSERVATIONS OF BRITISH DOCTORS. Br Med J. 1964 Jun 6;1(5396):1460–CONCL. doi: 10.1136/bmj.1.5396.1460. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Doll R., Peto R. Mortality in relation to smoking: 20 years' observations on male British doctors. Br Med J. 1976 Dec 25;2(6051):1525–1536. doi: 10.1136/bmj.2.6051.1525. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hammond E. C. Smoking in relation to the death rates of one million men and women. Natl Cancer Inst Monogr. 1966 Jan;19:127–204. [PubMed] [Google Scholar]
- Rawbone R. G., Coppin C. A., Guz A. Carbon monoxide in alveolar air as an index of exposure to cigarette smoke. Clin Sci Mol Med. 1976 Nov;51(5):495–501. doi: 10.1042/cs0510495. [DOI] [PubMed] [Google Scholar]
- Reid D. D., Hamilton P. J., McCartney P., Rose G., Jarrett R. J., Keen H. Smoking and other risk factors for coronary heart-disease in British civil servants. Lancet. 1976 Nov 6;2(7993):979–984. doi: 10.1016/s0140-6736(76)90830-8. [DOI] [PubMed] [Google Scholar]
- SCHWARTZ D., FLAMANT R., LELLOUCH J., DENOIX P. F. Results of a French survey on the role of tobacco, particularly inhalation, in different cancer sites. J Natl Cancer Inst. 1961 May;26:1085–1108. [PubMed] [Google Scholar]
- Schwartz D., Lellouch J., Anguera G., Beaumont J. L., Lenègre J. Tobacco and other factors in the etiology of ischemic heart disease in man: results of a retrospective survey. J Chronic Dis. 1966 Jan;19(1):35–55. doi: 10.1016/0021-9681(66)90150-0. [DOI] [PubMed] [Google Scholar]
- Seltzer C. C. An evaluation of the effect of smoking on coronary heart disease. I. Epidemiological evidence. JAMA. 1968 Jan 15;203(3):193–200. [PubMed] [Google Scholar]
- Wald N., Howard S., Smith P. G., Bailey A. Use of carboxyhaemoglobin levels to predict the development of diseases associated with cigarette smoking. Thorax. 1975 Apr;30(2):133–140. doi: 10.1136/thx.30.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wald N., Howard S., Smith P. G., Kjeldsen K. Association between atherosclerotic diseases and carboxyhaemoglobin levels in tobacco smokers. Br Med J. 1973 Mar 31;1(5856):761–765. doi: 10.1136/bmj.1.5856.761. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wald N., Idle M., Smith P. G. Carboxyhaemoglobin levels in smokers of filter and plain cigarettes. Lancet. 1977 Jan 15;1(8003):110–112. doi: 10.1016/s0140-6736(77)91702-0. [DOI] [PubMed] [Google Scholar]