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. 1978 Apr;33(2):243–249. doi: 10.1136/thx.33.2.243

Pulmonary function studies in healthy Pakistani adults.

D E Williams, R D Miller, W F Taylor
PMCID: PMC470877  PMID: 663884

Abstract

Predicted normal spirometric values have been shown to have significant geographical and ethnic variation. These variations are of epidemiological significance in determining the prevalence of disease and of clinical importance in measuring the effects on pulmonary function of various diseases. A total of 599 men were chosen from employees of a package manufacturer, a general hospital in Lahore, and a village in northern Pakistan; 94 students and staff of a women's college in Lahore were also studied. The forced vital capacity (FVC) was recorded from three satisfactory efforts, and the FVC, one second forced expiratory volume (FEV1), and maximal midexpiratory flow (MMF, or FEF25-75%) were calculated from the best FVC effort. The FVC and FEV1 in men were found to be similar to those of a group of emigrant Pakistanis and a north-western Indian population (Delhi) but higher than populations in south and eastern India. Pakistani women had values similar to those of women in northern India. None of the women smoked and, among Pakistani men, the smokers (285) averaged 6.7 pack years. While the FVC and FEV1 values did not differ between smokers and non-smokers, there was a significant difference in MMF (FEF25-75%) in the two groups. This latter finding corroborates studies on North American populations in which smokers generally have had a higher lifelong cigarette consumption. This confirms the MMF (FEF25-75%) to be a more sensitive test of subtle, asymptomatic changes in pulmonary function than the more widely used FVC and FEV1.

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Selected References

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  1. ABRAMOWITZ S., LEINER G. C., LEWIS W. A., SMALL M. J. VITAL CAPACITY IN THE NEGRO. Am Rev Respir Dis. 1965 Aug;92:287–292. doi: 10.1164/arrd.1965.92.2.287. [DOI] [PubMed] [Google Scholar]
  2. BARNHARD H. J., PIERCE J. A., JOYCE J. W., BATES J. H. Roentgenographic determination of total lung capacity. A new method evaluated in health, emphysema and congestive heart failure. Am J Med. 1960 Jan;28:51–60. doi: 10.1016/0002-9343(60)90222-9. [DOI] [PubMed] [Google Scholar]
  3. BERGLUND E., BIRATH G., BJURE J., GRIMBY G., KJELLMER I., SANDQVIST L., SODERHOLM B. Spirometric studies in normal subjects. I. Forced expirograms in subjects between 7 and 70 years of age. Acta Med Scand. 1963 Feb;173:185–192. [PubMed] [Google Scholar]
  4. Cotes J. E., Saunders M. J., Adam J. E., Anderson H. R., Hall A. M. Lung function in coastal and highland New Guineans--comparison with Europeans. Thorax. 1973 May;28(3):320–330. doi: 10.1136/thx.28.3.320. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cotes J. E., Ward M. P. Ventilatory capacity in normal Bhutanese. J Physiol. 1966 Oct;186(2):88P–89P. [PMC free article] [PubMed] [Google Scholar]
  6. Damon A. Negro-white differences in pulmonary function (vital capacity, timed vital capacity, and expiratory flow rate). Hum Biol. 1966 Dec;38(4):381–393. [PubMed] [Google Scholar]
  7. Densen P. M., Jones E. W., Bass H. E., Breuer J., Reed E. A survey of respiratory disease among New York City postal and transit workers. 2. Ventilatory function test results. Environ Res. 1969 Jul;2(4):277–296. doi: 10.1016/0013-9351(69)90032-2. [DOI] [PubMed] [Google Scholar]
  8. Dugdale A. E., Bolton J. M., Ganendran A. Respiratory function among Malaysian aboriginals. Thorax. 1971 Nov;26(6):740–743. doi: 10.1136/thx.26.6.740. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. FERRIS B. G., Jr, ANDERSON D. O., ZICKMANTEL R. PREDICTION VALUES FOR SCREENING TESTS OF PULMONARY FUNCTION. Am Rev Respir Dis. 1965 Feb;91:252–261. doi: 10.1164/arrd.1965.91.2.252. [DOI] [PubMed] [Google Scholar]
  10. Femi-Pearse D., Elebute E. A. Ventilatory function in healthy adult Nigerians. Clin Sci. 1971 Sep;41(3):203–211. doi: 10.1042/cs0410203. [DOI] [PubMed] [Google Scholar]
  11. HEPPER N. G., BLACK L. F., FOWLER W. S. RELATIONSHIPS OF LUNG VOLUME TO HEIGHT AND ARM SPAN IN NORMAL SUBJECTS AND IN PATIENTS WITH SPINAL DEFORMITY. Am Rev Respir Dis. 1965 Mar;91:356–362. doi: 10.1164/arrd.1965.91.3.356. [DOI] [PubMed] [Google Scholar]
  12. HEPPER N. G., FOWLER W. S., HELMHOLZ H. F., Jr Relationship of height to lung volume in healthy men. Dis Chest. 1960 Mar;37:314–320. [PubMed] [Google Scholar]
  13. Jain S. K., Ramiah T. J. Influence of age, height and body surface area on lung functions in healthy women 15-40 years old. Indian J Chest Dis. 1967 Jan;9(1):13–22. [PubMed] [Google Scholar]
  14. Jain S. K., Ramiah T. J. Normal standards of pulmonary function tests for healthy Indian men 15-40 years old: comparison of different regression equations (prediction formulae). Indian J Med Res. 1969 Aug;57(8):1453–1466. [PubMed] [Google Scholar]
  15. Johannsen Z. M., Erasmus L. D. Clinical spirometry in normal Bantu. Am Rev Respir Dis. 1968 Apr;97(4):585–597. doi: 10.1164/arrd.1968.97.4.585. [DOI] [PubMed] [Google Scholar]
  16. KORY R. C., CALLAHAN R., BOREN H. G., SYNER J. C. The Veterans Administration-Army cooperative study of pulmonary function. I. Clinical spirometry in normal men. Am J Med. 1961 Feb;30:243–258. doi: 10.1016/0002-9343(61)90096-1. [DOI] [PubMed] [Google Scholar]
  17. Lapp N. L., Amandus H. E., Hall R., Morgan W. K. Lung volumes and flow rates in black and white subjects. Thorax. 1974 Mar;29(2):185–188. doi: 10.1136/thx.29.2.185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Malik M. A., Moss E., Lee W. R. Prediction values for the ventilatory capacity in male West Pakistani workers in the United Kingdom. Thorax. 1972 Sep;27(5):611–619. doi: 10.1136/thx.27.5.611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. McFadden E. R., Jr, Linden D. A. A reduction in maximum mid-expiratory flow rate. A spirographic manifestation of small airway disease. Am J Med. 1972 Jun;52(6):725–737. doi: 10.1016/0002-9343(72)90078-2. [DOI] [PubMed] [Google Scholar]
  20. Miller G. J., Cotes J. E., Hall A. M., Salvosa C. B., Ashworth A. Lung function and exercise performance of healthy Caribbean men and women of African ethnic origin. Q J Exp Physiol Cogn Med Sci. 1972 Jul;57(3):325–341. doi: 10.1113/expphysiol.1972.sp002166. [DOI] [PubMed] [Google Scholar]
  21. Raghavan P., Nagendra A. S. A study of ventilatory functions in healthy Indian adults. J Postgrad Med. 1965 Jul;11(3):99–108. [PubMed] [Google Scholar]
  22. WU M. C., YANG S. P. Pulmonary function study in healthy Chinese. I. Lung volume and its subdivisions. Taiwan Yi Xue Hui Za Zhi. 1962 Feb 28;61:110–129. [PubMed] [Google Scholar]
  23. Woolcock A. J., Colman M. H., Blackburn C. R. Factors affecting normal values for ventilatory lung function. Am Rev Respir Dis. 1972 Nov;106(5):692–709. doi: 10.1164/arrd.1972.106.5.692. [DOI] [PubMed] [Google Scholar]

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