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. 1978 Jun;33(3):315–321. doi: 10.1136/thx.33.3.315

Mechanical properties of the lung in extrinsic allergic alveolitis.

C P Warren, K S Tse, R M Cherniack
PMCID: PMC470890  PMID: 684667

Abstract

The lung function of 14 patients with extrinsic allergic alveolitis caused by exposure to mouldy hay (farmer's lung) or to birds (bird fancier's lung) was studied one week and four to six weeks after the last exposure to antigen. These data, together with lung mechanics measured four weeks after antigen exposure, were compared with measurements in 34 healthy non-smoking control subjects. Shortly after exposure to antigen there were reduction in lung volumes, increased elastic recoil (reduced compliance), and varied effects on expiratory flow and reduced gas transfer. With time, lung volumes and gas transfer improved, but expiratory flow often remained decreased. The data on lung mechanics showed that reduced compliance was often found, but this increased recoil did not always produce high airflow indicating increased upstream airways resistance. Patients with a longer duration of the illness tended to have increased compliance (reduced recoil) and low airflow. These results show that the described pathological changes of airway involvement, fibrosis, and emphysema in allergic alveolitis are manifest in the lung function of patients with the disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Allen D. H., Williams G. V., Woolcock A. J. Bird breeder's hypersensitivity pneumonitis: progress studies of lung function after cessation of exposure to the provoking antigen. Am Rev Respir Dis. 1976 Sep;114(3):555–566. doi: 10.1164/arrd.1976.114.3.555. [DOI] [PubMed] [Google Scholar]
  2. BATES D. V., BOUCOT N. G., DORMER A. E. The pulmonary diffusing capacity in normal subjects. J Physiol. 1955 Aug 29;129(2):237–252. doi: 10.1113/jphysiol.1955.sp005350. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BATES D. V., WOOLF C. R., PAUL G. I. A report on the first two stages of the co-ordinated study of chronic bronchitis in the Department of Veterans Affairs, Canada. Med Serv J Can. 1962 Apr;18:211–303. [PubMed] [Google Scholar]
  4. Barbee R. A., Callies Q., Dickie H. A., Rankin J. The long-term prognosis in farmer's lung. Am Rev Respir Dis. 1968 Feb;97(2):223–231. doi: 10.1164/arrd.1968.97.2.223. [DOI] [PubMed] [Google Scholar]
  5. Cherniack R. M., Raber M. B. Normal standards for ventilatory function using an automated wedge spirometer. Am Rev Respir Dis. 1972 Jul;106(1):38–46. doi: 10.1164/arrd.1972.106.1.38. [DOI] [PubMed] [Google Scholar]
  6. Faux J. A., Wide L., Hargreave F. E., Longbottom J. L., Pepys J. Immunological aspects of respiratory allergy in budgerigar (Melopsittacus undulatus) fanciers. Clin Allergy. 1971 Jun;1(2):149–158. doi: 10.1111/j.1365-2222.1971.tb03014.x. [DOI] [PubMed] [Google Scholar]
  7. GOLDMAN H. I., BECKLAKE M. R. Respiratory function tests; normal values at median altitudes and the prediction of normal results. Am Rev Tuberc. 1959 Apr;79(4):457–467. doi: 10.1164/artpd.1959.79.4.457. [DOI] [PubMed] [Google Scholar]
  8. Gibson G. J., Pride N. B. Pulmonary mechanics in fibrosing alveolitis: the effects of lung shrinkage. Am Rev Respir Dis. 1977 Oct;116(4):637–647. doi: 10.1164/arrd.1977.116.4.637. [DOI] [PubMed] [Google Scholar]
  9. Hapke E. J., Seal R. M., Thomas G. O., Hayes M., Meek J. C. Farmer's lung. A clinical, radiographic, functional, and serological correlation of acute and chronic stages. Thorax. 1968 Sep;23(5):451–468. doi: 10.1136/thx.23.5.451. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hargreave F., Hinson K. F., Reid L., Simon G., McCarthy D. S. The radiological appearances of allergic alveolitis due to bird sensitivity (Bird fancier's lung). Clin Radiol. 1972 Jan;23(1):1–10. doi: 10.1016/s0009-9260(72)80126-0. [DOI] [PubMed] [Google Scholar]
  11. Jodoin G., Gibbs G. W., Macklem P. T., McDonald J. C., Becklake M. R. Early effects of asbestos exposure on lung function. Am Rev Respir Dis. 1971 Oct;104(4):525–535. doi: 10.1164/arrd.1971.104.4.525. [DOI] [PubMed] [Google Scholar]
  12. MILIC-EMILI J., MEAD J., TURNER J. M., GLAUSER E. M. IMPROVED TECHNIQUE FOR ESTIMATING PLEURAL PRESSURE FROM ESOPHAGEAL BALLOONS. J Appl Physiol. 1964 Mar;19:207–211. doi: 10.1152/jappl.1964.19.2.207. [DOI] [PubMed] [Google Scholar]
  13. Mead J., Turner J. M., Macklem P. T., Little J. B. Significance of the relationship between lung recoil and maximum expiratory flow. J Appl Physiol. 1967 Jan;22(1):95–108. doi: 10.1152/jappl.1967.22.1.95. [DOI] [PubMed] [Google Scholar]
  14. Ostrow D., Cherniack R. M. Resistance to airflow in patients with diffuse interstitial lung disease. Am Rev Respir Dis. 1973 Aug;108(2):205–210. doi: 10.1164/arrd.1973.108.2.205. [DOI] [PubMed] [Google Scholar]
  15. Schlueter D. P., Fink J. N., Sosman A. J. Pulmonary function in pigeon breeders' disease: a hypersensitivity pneumonitis. Ann Intern Med. 1969 Mar;70(3):457–470. doi: 10.7326/0003-4819-70-3-457. [DOI] [PubMed] [Google Scholar]
  16. Schofield N. C., Davies R. J., Cameron I. R., Green M. Small airways in fibrosing alveolitis. Am Rev Respir Dis. 1976 Jun;113(6):729–735. doi: 10.1164/arrd.1976.113.6.729. [DOI] [PubMed] [Google Scholar]
  17. Seal R. M., Hapke E. J., Thomas G. O., Meek J. C., Hayes M. The pathology of the acute and chronic stages of farmer's lung. Thorax. 1968 Sep;23(5):469–489. doi: 10.1136/thx.23.5.469. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Warren C. P. Extrinsic allergic alveolitis: a disease commoner in non-smokers. Thorax. 1977 Oct;32(5):567–569. doi: 10.1136/thx.32.5.567. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. doPico G. A., Reddan W. G., Chmelik F., Peters M. E., Reed C. E., Rankin J. The value of precipitating antibodies in screening for hypersensitivity pneumonitis. Am Rev Respir Dis. 1976 Apr;113(4):451–455. doi: 10.1164/arrd.1976.113.4.451. [DOI] [PubMed] [Google Scholar]

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