Abstract
The binding of ligands by a receptor can be expressed in an equation derived by a thermodynamic stoichiometric approach in which the stoichiometric equilibrium constants are all positive and real. An alternative binding equation can be derived algebraically in which the equilibrium constants can have values that are complex numbers. Some consequences of this situation are explored, and numerical values of the ghost equilibrium constants are evaluated for a number of ligand-receptor complexes.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Harris W. R. Thermodynamics of anion binding to human serum transferrin. Biochemistry. 1985 Dec 3;24(25):7412–7418. doi: 10.1021/bi00346a057. [DOI] [PubMed] [Google Scholar]
- Klotz I. M. Ligand--receptor interactions: facts and fantasies. Q Rev Biophys. 1985 Aug;18(3):227–259. doi: 10.1017/s0033583500000354. [DOI] [PubMed] [Google Scholar]
- Linse S., Brodin P., Drakenberg T., Thulin E., Sellers P., Elmdén K., Grundström T., Forsén S. Structure-function relationships in EF-hand Ca2+-binding proteins. Protein engineering and biophysical studies of calbindin D9k. Biochemistry. 1987 Oct 20;26(21):6723–6735. doi: 10.1021/bi00395a023. [DOI] [PubMed] [Google Scholar]
- Miura S., Ikeda-Saito M., Yonetani T., Ho C. Oxygen equilibrium studies of cross-linked asymmetrical cyanomet valency hybrid hemoglobins: models for partially oxygenated species. Biochemistry. 1987 Apr 21;26(8):2149–2155. doi: 10.1021/bi00382a013. [DOI] [PubMed] [Google Scholar]
- ROUGHTON F. J., OTIS A. B., LYSTER R. L. The determination of the individual equilibrium constants of the four intermediate reactions between oxygen and sheep haemoglobin. Proc R Soc Lond B Biol Sci. 1955 Aug 16;144(914):29–54. doi: 10.1098/rspb.1955.0032. [DOI] [PubMed] [Google Scholar]