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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1993 Aug 1;90(15):7210–7214. doi: 10.1073/pnas.90.15.7210

Integration of gene maps: chromosome 21.

S Lawrence 1, A Collins 1, B J Keats 1, M Hulten 1, N E Morton 1
PMCID: PMC47106  PMID: 8346237

Abstract

Physical, cytogenetic, and genetic data including microsatellite markers and a covering sequence-tagged site (STS) map have been entered into a location database and integrated into a summary map that subsumes a composite physical location, sex-specific genetic locations, cytogenetic and regional assignments, mouse homology, rank, and references. With the omission of 52 loci whose location is known only from cytogenetic assignment to an interval greater than 10 megabases, there are 198 loci in the covering STS map and an additional 145 loci. The physical length is consistent with 11 megabases for 21p and 39 megabases for 21q. With error filtration and allowance for high interference, the genetic length in males corresponds to the chiasma map (54.7 centimorgans), and the genetic length in females is 76.5 centimorgans. The relation between map integration and the STS paradigm is illustrated and discussed.

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Selected References

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  1. Burmeister M., Kim S., Price E. R., de Lange T., Tantravahi U., Myers R. M., Cox D. R. A map of the distal region of the long arm of human chromosome 21 constructed by radiation hybrid mapping and pulsed-field gel electrophoresis. Genomics. 1991 Jan;9(1):19–30. doi: 10.1016/0888-7543(91)90216-2. [DOI] [PubMed] [Google Scholar]
  2. Chumakov I., Rigault P., Guillou S., Ougen P., Billaut A., Guasconi G., Gervy P., LeGall I., Soularue P., Grinas L. Continuum of overlapping clones spanning the entire human chromosome 21q. Nature. 1992 Oct 1;359(6394):380–387. doi: 10.1038/359380a0. [DOI] [PubMed] [Google Scholar]
  3. Collins A., Keats B. J., Dracopoli N., Shields D. C., Morton N. E. Integration of gene maps: chromosome 1. Proc Natl Acad Sci U S A. 1992 May 15;89(10):4598–4602. doi: 10.1073/pnas.89.10.4598. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Daniels D. L., Plunkett G., 3rd, Burland V., Blattner F. R. Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes. Science. 1992 Aug 7;257(5071):771–778. doi: 10.1126/science.1379743. [DOI] [PubMed] [Google Scholar]
  5. Dausset J., Cann H., Cohen D., Lathrop M., Lalouel J. M., White R. Centre d'etude du polymorphisme humain (CEPH): collaborative genetic mapping of the human genome. Genomics. 1990 Mar;6(3):575–577. doi: 10.1016/0888-7543(90)90491-c. [DOI] [PubMed] [Google Scholar]
  6. Ferguson-Smith M. A. European approach to the Human Gene Project. FASEB J. 1991 Jan;5(1):61–65. doi: 10.1096/fasebj.5.1.1991586. [DOI] [PubMed] [Google Scholar]
  7. Ferguson-Smith M. A. European approach to the Human Gene Project. FASEB J. 1991 Jan;5(1):61–65. doi: 10.1096/fasebj.5.1.1991586. [DOI] [PubMed] [Google Scholar]
  8. Foote S., Vollrath D., Hilton A., Page D. C. The human Y chromosome: overlapping DNA clones spanning the euchromatic region. Science. 1992 Oct 2;258(5079):60–66. doi: 10.1126/science.1359640. [DOI] [PubMed] [Google Scholar]
  9. Gardiner K., Horisberger M., Kraus J., Tantravahi U., Korenberg J., Rao V., Reddy S., Patterson D. Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions. EMBO J. 1990 Jan;9(1):25–34. doi: 10.1002/j.1460-2075.1990.tb08076.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Goodfellow P. N. Human genome project. Variation is now the theme. Nature. 1992 Oct 29;359(6398):777–778. doi: 10.1038/359777a0. [DOI] [PubMed] [Google Scholar]
  11. Hultén M., Luciani J. M., Kirton V., Devictor-Vuillet M. The use and limitations of chiasma scoring with reference to human genetic mapping. Cytogenet Cell Genet. 1978;22(1-6):37–58. doi: 10.1159/000130917. [DOI] [PubMed] [Google Scholar]
  12. Keats B. J., Sherman S. L., Morton N. E., Robson E. B., Buetow K. H., Cartwright P. E., Chakravarti A., Francke U., Green P. P., Ott J. Guidelines for human linkage maps. An International System for Human Linkage Maps (ISLM, 1990). Ann Hum Genet. 1991 Jan;55(Pt 1):1–6. doi: 10.1111/j.1469-1809.1991.tb00392.x. [DOI] [PubMed] [Google Scholar]
  13. Keats B. J., Sherman S. L., Ott J. Report of the committee on linkage and gene order. Cytogenet Cell Genet. 1990;55(1-4):387–394. doi: 10.1159/000133023. [DOI] [PubMed] [Google Scholar]
  14. Laurie D. A., Hultén M. A. Further studies on chiasma distribution and interference in the human male. Ann Hum Genet. 1985 Jul;49(Pt 3):203–214. doi: 10.1111/j.1469-1809.1985.tb01694.x. [DOI] [PubMed] [Google Scholar]
  15. Lawrence S., Morton N. E., Cox D. R. Radiation hybrid mapping. Proc Natl Acad Sci U S A. 1991 Sep 1;88(17):7477–7480. doi: 10.1073/pnas.88.17.7477. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Morton N. E., Andrews V. MAP, an expert system for multiple pairwise linkage analysis. Ann Hum Genet. 1989 Jul;53(Pt 3):263–269. doi: 10.1111/j.1469-1809.1989.tb01793.x. [DOI] [PubMed] [Google Scholar]
  17. Morton N. E., Collins A., Lawrence S., Shields D. C. Algorithms for a location database. Ann Hum Genet. 1992 Jul;56(Pt 3):223–232. doi: 10.1111/j.1469-1809.1992.tb01147.x. [DOI] [PubMed] [Google Scholar]
  18. Morton N. E., Collins A. Standard maps of chromosome 10. Ann Hum Genet. 1990 Jul;54(Pt 3):235–251. doi: 10.1111/j.1469-1809.1990.tb00381.x. [DOI] [PubMed] [Google Scholar]
  19. Morton N. E. Gene maps and location databases. Ann Hum Genet. 1991 Jul;55(Pt 3):235–241. doi: 10.1111/j.1469-1809.1991.tb00418.x. [DOI] [PubMed] [Google Scholar]
  20. Olson M., Hood L., Cantor C., Botstein D. A common language for physical mapping of the human genome. Science. 1989 Sep 29;245(4925):1434–1435. doi: 10.1126/science.2781285. [DOI] [PubMed] [Google Scholar]
  21. Rao D. C., Morton N. E., Lindsten J., Hultén M., Yee S. A mapping function for man. Hum Hered. 1977;27(2):99–104. doi: 10.1159/000152856. [DOI] [PubMed] [Google Scholar]
  22. Shields D. C., Collins A., Buetow K. H., Morton N. E. Error filtration, interference, and the human linkage map. Proc Natl Acad Sci U S A. 1991 Aug 1;88(15):6501–6505. doi: 10.1073/pnas.88.15.6501. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Shows T. B., McAlpine P. J., Boucheix C., Collins F. S., Conneally P. M., Frézal J., Gershowitz H., Goodfellow P. N., Hall J. G., Issitt P. Guidelines for human gene nomenclature. An international system for human gene nomenclature (ISGN, 1987). Cytogenet Cell Genet. 1987;46(1-4):11–28. doi: 10.1159/000132471. [DOI] [PubMed] [Google Scholar]
  24. Weissenbach J., Gyapay G., Dib C., Vignal A., Morissette J., Millasseau P., Vaysseix G., Lathrop M. A second-generation linkage map of the human genome. Nature. 1992 Oct 29;359(6398):794–801. doi: 10.1038/359794a0. [DOI] [PubMed] [Google Scholar]

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