Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1979 Oct;34(5):670–676. doi: 10.1136/thx.34.5.670

Histocompatibility antigens in asthma: population and family studies.

C W Turton, L Morris, J A Buckingham, S D Lawler, M Turner-Warwick
PMCID: PMC471146  PMID: 515989

Abstract

One hundred and twenty-two patients with intrinsic asthma, extrinsic atopic asthma, or asthma with allergic bronchopulmonary aspergillosis were tissue typed for the HLA A, B, and C loci. No associations were found with any of the clinical groups, or with serum total IgE concentrations. Sixty-eight members of 10 families where more than one member was affected by asthma were studied. The segregation of haplotypes in siblings of the propositi who were or were not affected by asthma did not differ from the predicted segregation, and there were no differences when atopy or serum total IgE were considered. No biologically important association between HLA and asthma has been shown.

Full text

PDF
670

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blumenthal M. N., Amos D. B., Noreen H. Genetic mapping of Ir locus in man: linkage to second locus of HL-A. Science. 1974 Jun 21;184(4143):1301–1303. doi: 10.1126/science.184.4143.1301. [DOI] [PubMed] [Google Scholar]
  2. Brostoff J., Mowbray J. F., Kapoor A., Hollowell S. J., Rudolf M., Saunders K. B. 80% of patients with intrinsic asthma are homozygous for HLA W6. Is intrinsic asthma a recessive disease? Lancet. 1976 Oct 23;2(7991):872–873. doi: 10.1016/s0140-6736(76)90537-7. [DOI] [PubMed] [Google Scholar]
  3. Cromwell O., Pepys J., Parish W. E., Hughes E. G. Specific IgE antibodies to platinum salts in sensitized workers. Clin Allergy. 1979 Mar;9(2):109–117. doi: 10.1111/j.1365-2222.1979.tb01529.x. [DOI] [PubMed] [Google Scholar]
  4. LONGBOTTOM J. L., PEPYS J. PULMONARY ASPERGILLOSIS: DIAGNOSTIC AND IMMUNOLOGICAL SIGNIFICANCE OF ANTIGENS AND C-SUBSTANCE IN ASPERGILLUS FUMIGATUS. J Pathol Bacteriol. 1964 Jul;88:141–151. doi: 10.1002/path.1700880119. [DOI] [PubMed] [Google Scholar]
  5. Levine B. B., Stember R. H., Fotino M. Ragweed hay fever: genetic control and linkage to HL-A haplotypes. Science. 1972 Dec 15;178(4066):1201–1203. doi: 10.1126/science.178.4066.1201. [DOI] [PubMed] [Google Scholar]
  6. Malo J. L., Hawkins R., Pepys J. Studies in chronic allergic bronchopulmonary aspergillosis. 1. Clinical and physiological findings. Thorax. 1977 Jun;32(3):254–261. doi: 10.1136/thx.32.3.254. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Malo J. L., Pepys J., Simon G. Studies in chronic allergic bronchopulmonary aspergillosis. 2. Radiological findings. Thorax. 1977 Jun;32(3):262–268. doi: 10.1136/thx.32.3.262. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Marsh D. G., Bias W. B., Hsu S. H., Goodfriend L. Association of the HL-A7 cross-reacting group with a specific reaginic antibody response in allergic man. Science. 1973 Feb 16;179(4074):691–693. doi: 10.1126/science.179.4074.691. [DOI] [PubMed] [Google Scholar]
  9. Marsh D. G., Bias W. B., Ishizaka K. Genetic control of basal serum immunoglobulin E level and its effect on specific reaginic sensitivity. Proc Natl Acad Sci U S A. 1974 Sep;71(9):3588–3592. doi: 10.1073/pnas.71.9.3588. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Pepys J. Types of allergic reaction. Clin Allergy. 1973 Dec;3 (Suppl):491–509. doi: 10.1111/j.1365-2222.1973.tb03057.x. [DOI] [PubMed] [Google Scholar]
  11. Rachelefsky G., Park M. S., Siegel S., Terasaki P. I., Katz R., Saito S. Strong association between B-lymphocyte group-2 specificity and asthma. Lancet. 1976 Nov 13;2(7994):1042–1044. doi: 10.1016/s0140-6736(76)90964-8. [DOI] [PubMed] [Google Scholar]
  12. Scholz S., Ziegler E., Wüstner H., Braun-Falco O., Albert E. D. HLA family studies in patients with atopic dermatitis. Monogr Allergy. 1977;11:44–44. [PubMed] [Google Scholar]
  13. Sibbald B., Turner-Warwick M. Factors influencing the prevalence of asthma among first degree relatives of extrinsic and intrinsic asthmatics. Thorax. 1979 Jun;34(3):332–337. doi: 10.1136/thx.34.3.332. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Svejgaard A., Platz P., Ryder L. P., Nielsen L. S., Thomsen M. HL-A and disease associations--a survey. Transplant Rev. 1975;22:3–43. doi: 10.1111/j.1600-065x.1975.tb01550.x. [DOI] [PubMed] [Google Scholar]
  15. Thorsby E., Engeset A., Lie S. O. HL-A antigens and susceptibility to diseases. A study of patients with acute lymphoblastic leukaemia, Hodgkin's disease, and childhood asthma. Tissue Antigens. 1971;1(3):147–152. doi: 10.1111/j.1399-0039.1971.tb00091.x. [DOI] [PubMed] [Google Scholar]
  16. Turner M. W., Brostoff T. J., Wells R. S., Stokes C. R., Soothill J. F. HLA in eczema and hay fever. Clin Exp Immunol. 1977 Jan;27(1):43–47. [PMC free article] [PubMed] [Google Scholar]
  17. Wagatsuma Y., Yakura H., Nakayama E., Wakisaka A., Aizawa M. Inheritance of asthma in families and its linkage to HLA haplotypes. Acta Allergol. 1976 Dec;31(6):455–462. doi: 10.1111/j.1398-9995.1976.tb01495.x. [DOI] [PubMed] [Google Scholar]
  18. de Weck A. L. HLA and allergy. Monogr Allergy. 1977;11:3–18. [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES