Abstract
Uptake of 14C-propranolol by the lungs during a single passage through the pulmonary circulation was measured in ten patients at cardiac catheterisation. Mean lung uptake of propranolol was 75% in seven patients who were not previously taking the drug and 33% in three patients who were taking it as regular oral treatment. Lung uptake of propranolol in man is therefore considerable and is partly saturable by normal oral doses. This may alter the dose response relation for propranolol and a wide range of other drugs when given intravenously. The method used to study lung uptake is simple and might be suitable for studies of endothelial cell function in disease.
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Selected References
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- Anderson M. W., Orton T. C., Pickett R. D., Eling T. E. Accumulation of amines in the isolated perfused rabbit lung. J Pharmacol Exp Ther. 1974 May;189(2):456–466. [PubMed] [Google Scholar]
- Brown E. A. THe localization, metabolism and effects of drugs and toxicants in lung. Drug Metab Rev. 1974;3(1):33–87. doi: 10.3109/03602537408993738. [DOI] [PubMed] [Google Scholar]
- Dollery C. T., Junod A. F. Concentration of (+/-)-propranolol in isolated, perfused lungs of rat. Br J Pharmacol. 1976 May;57(1):67–71. doi: 10.1111/j.1476-5381.1976.tb07657.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Evans G. H., Nies A. S., Shand D. G. The disposition of propranolol. 3. Decreased half-life and volume of distribution as a result of plasma binding in man, monkey, dog and rat. J Pharmacol Exp Ther. 1973 Jul;186(1):114–122. [PubMed] [Google Scholar]
- Gallagher B., Christman D., Fowler J., MacGregor R., Wolf A. P., Som P., Ansari A. N., Atkins H. Radioisotope scintigraphy for the study of dynamics of amine regulation by the human lung. Chest. 1977 Feb;71(2 Suppl):282–284. doi: 10.1378/chest.71.2_supplement.282. [DOI] [PubMed] [Google Scholar]
- Hayes A., Cooper R. G. Studies on the absorption, distribution and excretion of propranolol in rat, dog and monkey. J Pharmacol Exp Ther. 1971 Feb;176(2):302–311. [PubMed] [Google Scholar]