Abstract
The chromium content was measured in the lungs of chromate workers, obtained at necropsy in six patients and at surgery in two. The mean chromium content of peripheral lung tissue was 36.7 micrograms per gm wet weight (range 0.50 to 130.2 micrograms) and that of the large airways was 0.51 micrograms per gm wet weight (range 0.22 to 0.99 micrograms). These means values were high compared with those from control lungs of a non-chromate exposed lung cancer patients--respectively 0.21 micrograms per gm in lung tissue and 0.11 micrograms per gm in the large bronchi. The longer the exposure period, the higher was the chromium content in the lungs. The concentration of chromium in the upper lobes was significantly higher than that in the lower lobes, suggesting regional differences either in clearance from or deposition in the lung. Moreover, it was apparent that the metal remained in the lungs long after exposure to chromate had ceased
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Selected References
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- BAETJER A. M., DAMRON C., BUDACZ V. The distribution and retention of chromium in men and animals. AMA Arch Ind Health. 1959 Aug;20(2):136–150. [PubMed] [Google Scholar]
- Green G. M., Jakab G. J., Low R. B., Davis G. S. Defense mechanisms of the respiratory membrane. Am Rev Respir Dis. 1977 Mar;115(3):479–514. doi: 10.1164/arrd.1977.115.3.479. [DOI] [PubMed] [Google Scholar]
- Lauweryns J. M., Baert J. H. Alveolar clearance and the role of the pulmonary lymphatics. Am Rev Respir Dis. 1977 Apr;115(4):625–683. doi: 10.1164/arrd.1977.115.4.625. [DOI] [PubMed] [Google Scholar]
- MITCHELL R. I. Retention of aerosol particles in the respiratory tract; a review. Am Rev Respir Dis. 1960 Nov;82:627–639. doi: 10.1164/arrd.1960.82.5.627. [DOI] [PubMed] [Google Scholar]
- Ohsaki Y., Abe S., Kimura K., Tsuneta Y., Mikami H., Murao M. Lung cancer in Japanese chromate workers. Thorax. 1978 Jun;33(3):372–374. doi: 10.1136/thx.33.3.372. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Taylor F. H. The relationship of mortality and duration of employment as reflected by a cohort of chromate workers. Am J Public Health Nations Health. 1966 Feb;56(2):218–229. doi: 10.2105/ajph.56.2.218. [DOI] [PMC free article] [PubMed] [Google Scholar]