Abstract
Eighty-two patients with histologically confirmed lung cancer were randomly allocated to receive either radiotherapy alone (2400-3200 rads, depending upon cell type) or the same dose of radiotherapy followed by four cycles of adriamycin and 5-fluorouracil. Eighty-one patients were evaluated and for the group as a whole survival was better in the undifferentiated group assigned to receive adjuvant chemotherapy but survival in the patients with squamous tumours was not significantly prolonged. The chemotherapy was not unduly toxic.
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Selected References
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- Carr D. T., Childs D. S., Jr, Lee R. E. Radiotherapy plus 5-FU compared to radiotherapy alone for inoperable and unresectable bronchogenic carcinoma. Cancer. 1972 Feb;29(2):375–380. doi: 10.1002/1097-0142(197202)29:2<375::aid-cncr2820290218>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
- Cohen J. L., Krant M. J., Shnider B. I., Matias P. I., Horton J., Baxter D. Radiation plus 5-fluorouracil (NSC-19893): clinical demonstration of an additive effect in bronchogenic carcinoma. Cancer Chemother Rep. 1971 Jun;55(3):253–258. [PubMed] [Google Scholar]
- Coy P. A randomized study of irradiation and vinblastine in lung cancer. Cancer. 1970 Oct;26(4):803–807. doi: 10.1002/1097-0142(197010)26:4<803::aid-cncr2820260410>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
- Deeley T. J. A clinical trial to compare two different tumour dose levels in the treatment of advanced carcinoma of the bronchus. Clin Radiol. 1966 Jul;17(3):299–301. doi: 10.1016/s0009-9260(66)80041-7. [DOI] [PubMed] [Google Scholar]
- KRANT M. J., CHALMERS T. C., DEDERICK M. M., HALL T. C., LEVENE M. B., MUENCH H., SHNIDER B. I., GOLD G. L., HUNTER C., BERSACK S. R. COMPARATIVE TRIAL OF CHEMOTHERAPY AND RADIOTHERAPY IN PATIENTS WITH NON-RESECTABLE CANCER OF THE LUNG. Am J Med. 1963 Sep;35:363–373. doi: 10.1016/0002-9343(63)90178-5. [DOI] [PubMed] [Google Scholar]
- Landgren R. C., Hussey D. H., Samuels M. L., Leary W. V. A randomized study comparing irradiation alone to irradiation plus procarbazine in inoperable bronchogenic carcinoma. Radiology. 1973 Aug;108(2):403–406. doi: 10.1148/108.2.403. [DOI] [PubMed] [Google Scholar]
- Peto R., Pike M. C., Armitage P., Breslow N. E., Cox D. R., Howard S. V., Mantel N., McPherson K., Peto J., Smith P. G. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples. Br J Cancer. 1977 Jan;35(1):1–39. doi: 10.1038/bjc.1977.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rees G. J., Bugaighis A., Anderson G. Treatment of advanced bronchogenic carcinoma with adriamycin and 5-fluorouracil. Br J Dis Chest. 1975 Jul;69:199–206. doi: 10.1016/0007-0971(75)90080-7. [DOI] [PubMed] [Google Scholar]