Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1981 Apr;36(4):252–258. doi: 10.1136/thx.36.4.252

Simultaneous occurrence of pulmonary interstitial fibrosis and alveolar cell carcinoma in one family.

F Beaumont, H M Jansen, J D Elema, L P ten Kate, H J Sluiter
PMCID: PMC471487  PMID: 6269246

Abstract

The coexistence of interstitial pulmonary fibrosis and alveolar cell carcinoma is well known. The familial occurrence of a combination of these two entities, however, is very rare. We present a family of which five members had diffuse interstitial pulmonary fibrosis. Three of them had in addition alveolar cell carcinoma. In a sixth family member, evidence of alveolar cell carcinoma was present without proven interstitial fibrosis. An autosomal dominant trait is suggested as the mode of inheritance of both interstitial fibrosis and alveolar cell carcinoma in this family.

Full text

PDF
252

Images in this article

253Image
on p.253
254Image
on p.254
254Image
on p.254
255Image
on p.255
256Image
on p.256

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. APPELMAN A. C., BUYTENDIJK H. J. [Chronic interstitial pneumonia (Hamman-Rich syndrome) in a family]. Ned Tijdschr Geneeskd. 1961 Sep 30;105:1928–1930. [PubMed] [Google Scholar]
  2. Adelman A. G., Chertkow G., Hayton R. C. Familial fibrocystic pulmonary dysplasia: a detailed family study. Can Med Assoc J. 1966 Sep 17;95(12):603–610. [PMC free article] [PubMed] [Google Scholar]
  3. BEAVER D. L., SHAPIRO J. L. A consideration of chronic pulmonary parenchymal inflammation and alveolar cell carcinoma with regard to a possible etiologic relationship. Am J Med. 1956 Dec;21(6):879–887. doi: 10.1016/0002-9343(56)90102-4. [DOI] [PubMed] [Google Scholar]
  4. BONANNI P. P., FRYMOYER J. W., JACOX R. F. A FAMILY STUDY OF IDIOPATHIC PULMONARY FIBROSIS. A POSSIBLE DYSPROTEINEMIC AND GENETICALLY DETERMINED DISEASE. Am J Med. 1965 Sep;39:411–421. doi: 10.1016/0002-9343(65)90208-1. [DOI] [PubMed] [Google Scholar]
  5. DONOHUE W. L., LASKI B., UCHIDA I., MUNN J. D. Familial fibrocystic pulmonary dysplasia and its relation to Hamman-Rich syndrome. Pediatrics. 1959 Nov;24:786–813. [PubMed] [Google Scholar]
  6. Davies B. H., Tuddenham E. G. Familial pulmonary fibrosis associated with oculocutaneous albinism and platelet function defect. A new syndrome. Q J Med. 1976 Apr;45(178):219–232. [PubMed] [Google Scholar]
  7. Driessen A. P., Scherpenisse L. A. Familiair voorkomende idffuse interstitiële longfibrose gecompliceerd door alveolaire-cellencarcinoom. Ned Tijdschr Geneeskd. 1970 Dec 5;114(49):2041–2045. [PubMed] [Google Scholar]
  8. Epler G. R., McLoud T. C., Gaensler E. A., Mikus J. P., Carrington C. B. Normal chest roentgenograms in chronic diffuse infiltrative lung disease. N Engl J Med. 1978 Apr 27;298(17):934–939. doi: 10.1056/NEJM197804272981703. [DOI] [PubMed] [Google Scholar]
  9. Fox B., Risdon R. A. Carcinoma of the lung and diffuse interstitial pulmonary fibrosis. J Clin Pathol. 1968 Jul;21(4):486–491. doi: 10.1136/jcp.21.4.486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Fraire A. E., Greenberg S. D. Carcinoma and diffuse interstitial fibrosis of lung. Cancer. 1973 May;31(5):1078–1086. doi: 10.1002/1097-0142(197305)31:5<1078::aid-cncr2820310507>3.0.co;2-1. [DOI] [PubMed] [Google Scholar]
  11. HUGHES E. W. FAMILIAL INTERSTITIAL PULMONARY FIBROSIS. Thorax. 1964 Nov;19:515–525. doi: 10.1136/thx.19.6.515. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Haddad R., Massaro D. Idiopathic diffuse interstitial pulmonary fibrosis (fibrosing alveolitis), atypical epithelial proliferation and lung cancer. Am J Med. 1968 Aug;45(2):211–219. doi: 10.1016/0002-9343(68)90039-9. [DOI] [PubMed] [Google Scholar]
  13. Hilton R. D., Pitkeathly D. A. Familial association of rheumatoid arthritis and fibrosing alveolitis. Ann Rheum Dis. 1974 May;33(3):191–195. doi: 10.1136/ard.33.3.191. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Hoste P., Willams J., Devriendt J., Lamont H., van der Straeten M. Familial diffuse interstitial pulmonary fibrosis associated with oculocutaneous albinism. Report of two cases with a family study. Scand J Respir Dis. 1979 Jun;60(3):128–134. [PubMed] [Google Scholar]
  15. Jansen H. M., The T. H., de Gast G. C., Huiges H. A., Esselink M. T., van der Wal A. M., Orie N. G. Immunoglobulin and complement inclusions in peripheral blood polymorphonuclear leucocytes of patients with bronchial carcinoma. Thorax. 1977 Dec;32(6):706–710. doi: 10.1136/thx.32.6.706. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Joishy S. K., Cooper R. A., Rowley P. T. Alveolar cell carcinoma in identical twins. Similarity in time of onset, histochemistry, and site of metastasis. Ann Intern Med. 1977 Oct;87(4):447–450. doi: 10.7326/0003-4819-87-4-447. [DOI] [PubMed] [Google Scholar]
  17. Jones A. W. Alveolar cell carcinoma occurring in idiopathic interstitial pulmonary fibrosis. Br J Dis Chest. 1970 Apr;64(2):78–84. doi: 10.1016/s0007-0971(70)80032-8. [DOI] [PubMed] [Google Scholar]
  18. KOCH B. FAMILIAL FIBROCYSTIC PULMONARY DYSPLASIA: OBSERVATIONS IN ONE FAMILY. Can Med Assoc J. 1965 Apr 10;92:801–808. [PMC free article] [PubMed] [Google Scholar]
  19. Limas C., Japaze H., Garcia-Bunuel R. "Scar" carcinoma of the lung. Chest. 1971 Feb;59(2):219–222. doi: 10.1378/chest.59.2.219. [DOI] [PubMed] [Google Scholar]
  20. Lutwyche V. U. Another presentation of fibrosing alveolitis and alveolar cell carcinoma. Chest. 1976 Aug;70(2):292–293. doi: 10.1378/chest.70.2.292. [DOI] [PubMed] [Google Scholar]
  21. MEYER E. C., LIEBOW A. A. RELATIONSHIP OF INTERSTITIAL PNEUMONIA HONEYCOMBING AND ATYPICAL EPITHELIAL PROLIFERATION TO CANCER OF THE LUNG. Cancer. 1965 Mar;18:322–351. doi: 10.1002/1097-0142(196503)18:3<322::aid-cncr2820180310>3.0.co;2-j. [DOI] [PubMed] [Google Scholar]
  22. SPAIN D. M. The association of terminal bronchiolar carcinoma with chronic interstitial inflammation and fibrosis of the lungs. Am Rev Tuberc. 1957 Oct;76(4):559–566. doi: 10.1164/artpd.1957.76.4.559. [DOI] [PubMed] [Google Scholar]
  23. Solliday N. H., Williams J. A., Gaensler E. A., Coutu R. E., Carrington C. B. Familial chronic interstitial pneumonia. Am Rev Respir Dis. 1973 Aug;108(2):193–204. doi: 10.1164/arrd.1973.108.2.193. [DOI] [PubMed] [Google Scholar]
  24. Swaye P., Van Ordstrand H. S., McCormack L. J., Wolpaw S. E. Familial Hamman-Rich syndrome. Report of eight cases. Dis Chest. 1969 Jan;55(1):7–12. doi: 10.1378/chest.55.1.7. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES