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. 1981 May;36(5):366–369. doi: 10.1136/thx.36.5.366

Carbon monoxide in breath in relation to smoking and carboxyhaemoglobin levels.

N J Wald, M Idle, J Boreham, A Bailey
PMCID: PMC471511  PMID: 7314006

Abstract

Carboxyhaemoglobin (COHb) levels were studied in 11 249 men. The distribution among the 2613 men who smoked cigarettes was well separated from that in 6641 non-smokers (including ex-smokers). The distribution for 2005 cigar and pipe smokers was intermediate, though some of the highest COHb levels occurred in cigar smokers. Using a COHb cut-off level of 2%, 81% of cigarette smokers, 35% of cigar and pipe smokers, and 1.0% of non-smokers had raised COHb levels. In a subsidiary experiment alveolar air samples were collected from 162 smokers and 25 non-smokers using a simple breath sampling technique. Carbon monoxide concentrations in alveolar breath were highly correlated with COHb levels (r = 0.97) indicating that COHb levels can be estimated reliably by measuring the concentration of carbon monoxide in breath. Alveolar carbon monoxide measurement is thus a simple method of estimating whether a person is likely to be a smoker.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Coburn R. F., Forster R. E., Kane P. B. Considerations of the physiological variables that determine the blood carboxyhemoglobin concentration in man. J Clin Invest. 1965 Nov;44(11):1899–1910. doi: 10.1172/JCI105296. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Coburn R. F., Forster R. E., Kane P. B. Considerations of the physiological variables that determine the blood carboxyhemoglobin concentration in man. J Clin Invest. 1965 Nov;44(11):1899–1910. doi: 10.1172/JCI105296. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cohen S. I., Perkins N. M., Ury H. K., Goldsmith J. R. Carbon monoxide uptake in cigarette smoking. Arch Environ Health. 1971 Jan;22(1):55–60. doi: 10.1080/00039896.1971.10665815. [DOI] [PubMed] [Google Scholar]
  4. Goldsmith J. R., Aronow W. S. Carbon monoxide and coronary heart disease: A review. Environ Res. 1975 Oct;10(2):236–248. doi: 10.1016/0013-9351(75)90087-0. [DOI] [PubMed] [Google Scholar]
  5. Goldsmith J. R., Landaw S. A. Carbon monoxide and human health. Science. 1968 Dec 20;162(3860):1352–1359. doi: 10.1126/science.162.3860.1352. [DOI] [PubMed] [Google Scholar]
  6. JONES R. H., ELLICOTT M. F., CADIGAN J. B., GAENSLER E. A. The relationship between alveolar and blood carbon monoxide concentrations during breathholding; simple estimation of COHb saturation. J Lab Clin Med. 1958 Apr;51(4):553–564. [PubMed] [Google Scholar]
  7. McIlvaine P. M., Nelson W. C., Bartlett D., Jr Temporal variation of carboxyhemoglobin concentrations. Arch Environ Health. 1969 Jul;19(1):83–91. doi: 10.1080/00039896.1969.10666808. [DOI] [PubMed] [Google Scholar]
  8. RINGOLD A., GOLDSMITH J. R., HELWIG H. L., FINN R., SCHUETTE F. Estimating recent carbon monoxide exposures. A rapid method. Arch Environ Health. 1962 Oct;5:308–318. doi: 10.1080/00039896.1962.10663288. [DOI] [PubMed] [Google Scholar]
  9. Rawbone R. G., Coppin C. A., Guz A. Carbon monoxide in alveolar air as an index of exposure to cigarette smoke. Clin Sci Mol Med. 1976 Nov;51(5):495–501. doi: 10.1042/cs0510495. [DOI] [PubMed] [Google Scholar]
  10. Rea J. N., Tyrer P. J., Kasap H. S., Beresford S. A. Expired air carbon monoxide, smoking, and other variables. A community study. Br J Prev Soc Med. 1973 May;27(2):114–120. doi: 10.1136/jech.27.2.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Vogt T. M., Selvin S., Widdowson G., Hulley S. B. Expired air carbon monoxide and serum thiocyanate as objective measures of cigarette exposure. Am J Public Health. 1977 Jun;67(6):545–549. doi: 10.2105/ajph.67.6.545. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Wald N., Howard S., Smith P. G., Bailey A. Use of carboxyhaemoglobin levels to predict the development of diseases associated with cigarette smoking. Thorax. 1975 Apr;30(2):133–140. doi: 10.1136/thx.30.2.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Wald N., Idle M., Bailey A. Carboxyhaemoglobin levels and inhaling habits in cigarette smokers. Thorax. 1978 Apr;33(2):201–206. doi: 10.1136/thx.33.2.201. [DOI] [PMC free article] [PubMed] [Google Scholar]

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