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. 1981 May;36(5):382–386. doi: 10.1136/thx.36.5.382

Dose-dependency of theophylline clearance and protein binding.

J A Fleetham, C E Bird, K Nakatsu, R D Wigle, P W Munt
PMCID: PMC471514  PMID: 7314008

Abstract

Dose-dependency in theophylline pharmacokinetics and protein binding characteristics was examined in 10 healthy male volunteers. Theophylline disposition was determined after an intravenous infusion of both 1 mg/kg and 6 mg/kg aminophylline in a randomised crossover study. There was considerable intrasubject variability in theophylline clearance but no significant dose-dependency. Theophylline protein binding was assessed by equilibrium dialysis at varying theophylline concentrations. The percentage of free non-protein bound theophylline was significantly increased at high theophylline concentrations. This increase in free theophylline would lead to a non-linear increase in the risk of toxicity with increasing drug concentration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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