. Author manuscript; available in PMC: 2016 Nov 1.

Published in final edited form as: Microcirculation. 2015 Nov;22(8):724–736. doi: 10.1111/micc.12247

Table 4.

Hemodynamics following exposure to normoxia (Norm) or chronic hypoxia (CH) for 7 or 21 days.

	Norm	CH 7 days	CH 21 days	ANOVA	Trend
Parameter
HR	462.2 ± 58.5	479.6 ± 83.9	477.3 ± 71.4	0.89	0.7
ESP (mm Hg)	19.2 ± 1.6	30.1 ± 5.4	30.6 ± 4.7	<0.0001	<0.0001
EDP (mm Hg)	1.0 ± 0.4	0.7 ± 1.2	2.2 ± 1.1	0.03	0.04
ESV (µL)	31.0 ± 15.4	31.1 ± 14.4	33.6 ± 12.7	0.93	0.73
EDV (µL)	47.2 ± 20.2	45.2 ± 13.4	48.9 ± 19.5	0.93	0.86
SV (µL)	25.5 ± 4.5	23.9 ± 6.2	28.5 ± 6.1	0.33	0.33
*CO (µLmin⁻¹)**	11847 ± 2893	11086 ± 2350	13227 ± 1497	0.32	0.28
*E_a (mm HgµL⁻¹)**	0.8 ± 0.2	1.5 ± 0.9	1.2 ± 0.5	0.11	0.22
Systolic Indices
EF (%)	62.7 ± 22.5	58.4 ± 20.4	65.0 ± 20.3	0.84	0.84
*dP/dt _max (mm Hgsec⁻¹)**	1074 ± 291	1909 ± 710	1514 ±331	0.02	0.11
*SW (mm HgµL)**	303.0 ± 45.0	422.8 ± 151.5	430.7 ± 82.3	0.06	0.03
*E_es (mm Hg µL⁻¹)**	2.0 ± 1.3	1.8 ± 1.1	1.6 ± 0.7	0.22	0.52
*dP/dt_max -EDV (mm Hgsec⁻¹* µL⁻¹)**	63.2 ± 49.9	36.5 ± 30.2	22.2 ± 7.4	0.19	0.08
PRSW (mm Hg)	19.9 ± 11.4	24.1 ± 6.6	18.8 ± 5.5	0.54	0.83
Diastolic Indices
*-dP/dt_min (mm Hgsec⁻¹)**	984 ± 204	1907 ± 808	1564 ± 514	0.02	0.07
Tau (ms)	10.7 ± 3.3	7.9 ± 1.9	9.9 ± 2.3	0.13	0.53
RV-PA Coupling
E_es/E_a	2.2 ± 1.3	1.3 ± 0.9	1.5 ± 0.8	0.31	0.27

HR = heart rate; ESP = end-systolic pressure; EDP = end-diastolic pressure; ESV = end-systolic volume; EDV = end-diastolic volume; SV = stroke volume; CO = cardiac output; E_a = arterial elastance; EF = ejection fraction; dP/dt_max = maximum rate of pressure change; SW = stroke work; E_es = end-systolic elastance; PRSW = preload recruitable stroke work; dP/dt_min = minimal rate of pressure change; Tau = isovolumic relaxation constant (Weiss method). Data are from 7 animals/group, except E_es, dP/dt_max-EDV, PRSW, and E_es/E_a which are from 5 animals/group. P-values are for one-way ANOVA (ANOVA) with post-hoc testing for linear trend (Trend).