Abstract
Bronchoconstriction was induced in asthmatic patients by means of isocapnic hyperventilation with dry air. Responses both within a day and between days did not differ significantly and corresponded closely with those observed after exercise. The mean fall in forced expiratory volume in one second (FEV1) observed with both techniques was equivalent to 36%. Isocapnic hyperventilation with dry air, as used in this study, was a potent stimulus and provoked a reproducible response. The method was physically less demanding than exercise and was more acceptable to patients.
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Selected References
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- Anderson S. D., Connolly N. M., Godfrey S. Comparison of bronchoconstriction induced by cycling and running. Thorax. 1971 Jul;26(4):396–401. doi: 10.1136/thx.26.4.396. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Anderson S. D., Silverman M., König P., Godfrey S. Exercise-induced asthma. Br J Dis Chest. 1975 Jan;69(1):1–39. doi: 10.1016/0007-0971(75)90053-4. [DOI] [PubMed] [Google Scholar]
- Chen W. Y., Horton D. J. Heat and water loss from the airways and exercise-induced asthma. Respiration. 1977;34(6):305–313. doi: 10.1159/000193842. [DOI] [PubMed] [Google Scholar]
- Clark T. J., Freedman S., Campbell E. J., Winn R. R. The ventilatory capacity of patients with chronic airways obstruction. Clin Sci. 1969 Apr;36(2):307–316. [PubMed] [Google Scholar]
- Deal E. C., Jr, McFadden E. R., Jr, Ingram R. H., Jr, Breslin F. J., Jaeger J. J. Airway responsiveness to cold air and hyperpnea in normal subjects and in those with hay fever and asthma. Am Rev Respir Dis. 1980 Apr;121(4):621–628. doi: 10.1164/arrd.1980.121.4.621. [DOI] [PubMed] [Google Scholar]
- Deal E. C., Jr, McFadden E. R., Jr, Ingram R. H., Jr, Jaeger J. J. Hyperpnea and heat flux: initial reaction sequence in exercise-induced asthma. J Appl Physiol Respir Environ Exerc Physiol. 1979 Mar;46(3):476–483. doi: 10.1152/jappl.1979.46.3.476. [DOI] [PubMed] [Google Scholar]
- Jones R. S. Assessment of respiratory function in the asthmatic child. Br Med J. 1966 Oct 22;2(5520):972–975. doi: 10.1136/bmj.2.5520.972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McFadden E. R., Jr, Ingram R. H., Jr Exercise-induced asthma: Observations on the initiating stimulus. N Engl J Med. 1979 Oct 4;301(14):763–769. doi: 10.1056/NEJM197910043011406. [DOI] [PubMed] [Google Scholar]
- Miller G. J., Davies B. H., Cole T. J., Seaton A. Comparison of the bronchial response to running and cycling in asthma using an improved definition of the response to work. Thorax. 1975 Jun;30(3):306–311. doi: 10.1136/thx.30.3.306. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zeballos R. J., Shturman-Ellstein R., McNally J. F., Jr, Hirsch J. E., Souhrada J. F. The role of hyperventilation in exercise-induced bronchoconstriction. Am Rev Respir Dis. 1978 Nov;118(5):877–884. doi: 10.1164/arrd.1978.118.5.877. [DOI] [PubMed] [Google Scholar]