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. 1967 Sep;22(5):408–421. doi: 10.1136/thx.22.5.408

Cystic thymomas and thymic cysts

A Review

N H Dyer 1,1
PMCID: PMC471679  PMID: 6050288

Abstract

Six cases of large thymic cyst are described; five were cystic thymomas and one was nonneoplastic. Two of the thymomas were not only grossly degenerate but showed severe chronic inflammatory change, so that the diagnosis might be missed. The classification of cysts into congenital, inflammatory, and neoplastic groups is discussed. Cystic teratomata of the thymus, lymphatic cysts, and bronchogenic cysts are classed separately since thymic location does not affect their natural history. Cystic thymomas are still not well known clinically, and the literature on the subject is reviewed. It is probable that quite a few non-specific cysts of the anterior mediastinum are of thymic origin.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABELL M. R. Mediastinal cysts. AMA Arch Pathol. 1956 May;61(5):360–379. [PubMed] [Google Scholar]
  2. ADAMS J. E. LEUKEMOGENIC THYMOMA: REPORT OF A UNIQUE CASE. Am J Clin Pathol. 1963 Aug;40:173–182. doi: 10.1093/ajcp/40.2.173. [DOI] [PubMed] [Google Scholar]
  3. ALARCON SEGOVIA D., GALBRAITH R. F., MALDONADO J. E., HOWARD F. M., Jr SYSTEMIC LUPUS ERYTHEMATOSUS FOLLOWING THYMECTOMY FOR MYSTHENIA GRAVIS. REPORT OF TWO CASES. Lancet. 1963 Sep 28;2(7309):662–665. doi: 10.1016/s0140-6736(63)90456-2. [DOI] [PubMed] [Google Scholar]
  4. ANDRITSAKIS G. D., SOMMERS S. C. Criteria of thymic cancer and clinical correlations of thymic tumors. J Thorac Surg. 1959 Mar;37(3):273–290. [PubMed] [Google Scholar]
  5. BERNATZ P. E., HARRISON E. G., CLAGETT O. T. Thymoma: a clinicopathologic study. J Thorac Cardiovasc Surg. 1961 Oct;42:424–444. [PubMed] [Google Scholar]
  6. BETTEGA J. L., TRAMUJAS A., DA COSTA I. A., JAMUR A. Cisto tímico do mediastino. Rev Bras Tuberc Doencas Torac. 1957 Oct;25(186):1387–1398. [PubMed] [Google Scholar]
  7. BIRCH C. A., COOKE K. B., DREW C. E., LONDON D. R., MACKENZIE D. H., MILNE M. D. HYPERGLOBULINAEMIC PURPURA DUE TO A THYMIC TUMOUR. Lancet. 1964 Mar 28;1(7335):693–697. doi: 10.1016/s0140-6736(64)91520-x. [DOI] [PubMed] [Google Scholar]
  8. Bieger R. C., McAdams A. J. Thymic cysts. Arch Pathol. 1966 Dec;82(6):535–541. [PubMed] [Google Scholar]
  9. Blalock A., Mason M. F., Morgan H. J., Riven S. S. MYASTHENIA GRAVIS AND TUMORS OF THE THYMIC REGION: REPORT OF A CASE IN WHICH THE TUMOR WAS REMOVED. Ann Surg. 1939 Oct;110(4):544–561. doi: 10.1097/00000658-193910000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. CRELLIN J. A., PUGH T. F., JANTON O. H., Jr Benign thymic cyst: a case report. Dis Chest. 1950 Aug;18(2):154–161. doi: 10.1378/chest.18.2.154. [DOI] [PubMed] [Google Scholar]
  11. EFFLER D. B., MCCORMACK L. J. Thymic neoplasms. J Thorac Surg. 1956 Jan;31(1):60-77; discussion, 77-82. [PubMed] [Google Scholar]
  12. EHRENREICH T., ALLEN A. C. Myasthenia gravis following extirpation of an asymptomatic thymoma. Cancer. 1958 Jan-Feb;11(1):173–180. doi: 10.1002/1097-0142(195801/02)11:1<173::aid-cncr2820110129>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
  13. GIRAUD G., NEGRE E., THEVENET A., BERAUD P. [Hydatid cyst of the thymus]. Presse Med. 1963 Jun 1;71:1375–1376. [PubMed] [Google Scholar]
  14. HASNER E. THYMOMAS. Acta Chir Scand. 1963 Jul-Aug;126:58–65. [PubMed] [Google Scholar]
  15. HAVARD C. W., SCOTT R. B. Thymic tumour and erythroblastic aplasia. Report of three cases and a review of the syndrome. Br J Haematol. 1960 Apr;6:178–190. doi: 10.1111/j.1365-2141.1960.tb06231.x. [DOI] [PubMed] [Google Scholar]
  16. HERLITZKA A. J., GALE J. W. Tumors and cysts of the mediastinum; survey of one hundred seventy-four mediastinal tumors treated surgically during the past eighteen years at the University of Wisconsin Hospitals. AMA Arch Surg. 1958 May;76(5):697–706. [PubMed] [Google Scholar]
  17. HUBBELL D. S., LIEBOW A. A. Thymic tumors characterized by lymphangioendothelial structure. Am J Pathol. 1952 May-Jun;28(3):321–345. [PMC free article] [PubMed] [Google Scholar]
  18. IVERSON L. Thymoma; a review and reclassification. Am J Pathol. 1956 Jul-Aug;32(4):695–719. [PMC free article] [PubMed] [Google Scholar]
  19. KOUGH R. H., BARNES W. T. THYMOMA ASSOCIATED WITH ERYTHROID APLASIA, BULLOUS SKIN ERUPTION, AND THE LUPUS ERYTHEMATOSUS CELL PHENOMENON; REPORT OF A CASE. Ann Intern Med. 1964 Aug;61:308–315. doi: 10.7326/0003-4819-61-2-308. [DOI] [PubMed] [Google Scholar]
  20. KRECH W. G., STOREY C. F., UMIKER W. C. Thymic cysts; a review of the literature and report of two cases. J Thorac Surg. 1954 May;27(5):477–493. [PubMed] [Google Scholar]
  21. LANGSTON J. D., WAGMAN G. F., DICKENMAN R. C. Granulomatous myocarditis and myositis associated with thymoma. Arch Pathol. 1959 Oct;68:367–373. [PubMed] [Google Scholar]
  22. LARMI T. K. Clinical and histopathologic observations in surgery of the thymus. Acta Chir Scand. 1960 Jun 30;119:204–205. [PubMed] [Google Scholar]
  23. LEGG M. A., BRADY W. J. PATHOLOGY AND CLINICAL BEHAVIOR OF THYMOMAS. A SURVEY OF 51 CASES. Cancer. 1965 Sep;18:1131–1144. doi: 10.1002/1097-0142(196509)18:9<1131::aid-cncr2820180914>3.0.co;2-f. [DOI] [PubMed] [Google Scholar]
  24. LINDSKOG G. E. Cystic thymoma-the possibility of confusion with tuberculoma. Am Rev Tuberc. 1954 Jul;70(1):155–160. doi: 10.1164/art.1954.70.1.155. [DOI] [PubMed] [Google Scholar]
  25. MORRISON I. M. Tumours and cysts of the mediastinum. Thorax. 1958 Dec;13(4):294–307. doi: 10.1136/thx.13.4.294. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. O'GARA R. W., HORN R. C., Jr, ENTERLINE H. T. Tumors of the anterior mediastinum. Cancer. 1958 May-Jun;11(3):562–590. doi: 10.1002/1097-0142(195805/06)11:3<562::aid-cncr2820110318>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  27. PACHTER M. R., LATTES R. MEDIASTINAL CYSTS: A CLINICOPATHOLOGIC STUDY OF TWENTY CASES. Dis Chest. 1963 Oct;44:416–421. doi: 10.1378/chest.44.4.416. [DOI] [PubMed] [Google Scholar]
  28. PEABODY J. W., Jr, STRUG L. H., RIVES J. D. Mediastinal tumors; a survey of modern concepts in diagnosis and management. AMA Arch Intern Med. 1954 Jun;93(6):875–893. doi: 10.1001/archinte.1954.00240300069007. [DOI] [PubMed] [Google Scholar]
  29. PERERA H. W., WILSON J. R. Anterior inferior mediastinal thymoma-case report. Br J Dis Chest. 1962 Jan;56:44–44. doi: 10.1016/s0007-0971(62)80034-5. [DOI] [PubMed] [Google Scholar]
  30. PODOLSKY S., EHRLICH E. W., HOWARD J. M. Congenital thymic cyst attached to the pericardium. Case report and review of the literature. Dis Chest. 1962 Dec;42:642–644. doi: 10.1378/chest.42.6.642. [DOI] [PubMed] [Google Scholar]
  31. RAMOS A. J. Presentation of case. J Am Med Assoc. 1956 Apr 14;160(15):1317–1319. [PubMed] [Google Scholar]
  32. RINGERTZ N., LIDHOLM S. O. Mediastinal tumors and cysts. J Thorac Surg. 1956 Apr;31(4):458–487. [PubMed] [Google Scholar]
  33. River G. L. Erythroid aplasia following thymomectomy. Report of a case with a positive lupus erythematosus cell preparation and elevated plasma erythropoietin level. JAMA. 1966 Aug 29;197(9):726–728. doi: 10.1001/jama.197.9.726. [DOI] [PubMed] [Google Scholar]
  34. SABISTON D. C., Jr, SCOTT H. W., Jr Primary neoplasms and cysts of the mediastinum. Ann Surg. 1952 Nov;136(5):777–797. doi: 10.1097/00000658-195211000-00003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. SCHOLZ D. A., BAHN R. C. Thymic tumors associated with Cushing's syndrome: review of three cases. Proc Staff Meet Mayo Clin. 1959 Sep 2;34:433–441. [PubMed] [Google Scholar]
  36. SEYBOLD W. D., McDONALD J. R., CLAGETT O. R., GOOD C. A. Tumors of the thymus. J Thorac Surg. 1950 Aug;20(2):195–215. [PubMed] [Google Scholar]
  37. Shields T. W., Fox R. T., Lees W. M. Thymic tumors. Classification and treatment. Arch Surg. 1966 Apr;92(4):617–622. doi: 10.1001/archsurg.1966.01320220173027. [DOI] [PubMed] [Google Scholar]
  38. THOMSON A. D., THACKRAY A. C. The histology of tumours of the thymus. Br J Cancer. 1957 Sep;11(3):348–358. doi: 10.1038/bjc.1957.42. [DOI] [PMC free article] [PubMed] [Google Scholar]
  39. VIDEBAEK A., THOMSEN G. Tumours of the thymic region. Follow-up on 36 operated cases. Acta Radiol Suppl. 1959;188:261–275. doi: 10.1177/0284185159052s18824. [DOI] [PubMed] [Google Scholar]
  40. WILLIOT J., DELPORTE F., DEPRE C. A PROPOS D'UNE OBSERVATION DE THYMOME KYSTIQUE. Brux Med. 1964 Dec 6;44:1311–1314. [PubMed] [Google Scholar]
  41. Wilkins E. W., Jr, Edmunds L. H., Jr, Castleman B. Cases of thymoma at the Massachusetts General Hospital. J Thorac Cardiovasc Surg. 1966 Sep;52(3):322–330. [PubMed] [Google Scholar]
  42. YAMAKAWA K., TSUCHIYA Y., NAITO S., KAWAGUCHI J. S. A case report of thymic cyst. Dis Chest. 1961 May;39:542–545. doi: 10.1378/chest.39.5.542. [DOI] [PubMed] [Google Scholar]

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