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. 1981 Sep;36(9):688–692. doi: 10.1136/thx.36.9.688

Ferritin, finger clubbing, and lung disease.

J M Shneerson, B M Jones
PMCID: PMC471702  PMID: 7314044

Abstract

The serum ferritin concentration has been determined by an immunoradiometric assay in 90 subjects with a variety of pulmonary diseases. No association between ferritin concentrations and finger clubbing has been found in any of the diseases studied. Ferritin levels were significantly raised in the subjects with bronchial carcinoma, but were not useful in monitoring recurrence of the tumour. Pulmonary artery and pulmonary vein ferritin concentrations were similar to systemic venous concentrations. It is therefore unlikely that the tumour releases ferritin into the pulmonary circulation. Ferritin levels were raised in patients with acute pneumonias but did not correlate with the total white cell count or erythrocyte sedimentation rate. Serum ferritin concentrations were also increased in a variety of chronic lung diseases but were normal in subjects with asbestosis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aungst C. W. Ferritin in body fluids. J Lab Clin Med. 1968 Mar;71(3):517–522. [PubMed] [Google Scholar]
  2. BAEZ S., MAZUR A., SHORR E. Hepatorenal factors in circulatory homeostasis. XX. Antidiuretic action of hepatic vasodepressor, VDM (ferritin). Am J Physiol. 1950 Jul 1;162(1):198–212. doi: 10.1152/ajplegacy.1950.162.1.198. [DOI] [PubMed] [Google Scholar]
  3. Buffe D., Rimbaut C. Alpha2-H-globulin, a hepatic glycoferroprotein: characterization and clinical significance. Ann N Y Acad Sci. 1975 Aug 22;259:417–426. doi: 10.1111/j.1749-6632.1975.tb25439.x. [DOI] [PubMed] [Google Scholar]
  4. Coombes R. C., Ellison M. L., Neville A. M. Biochemical markers in bronchogenic carcinoma. Br J Dis Chest. 1978 Oct;72(4):263–287. [PubMed] [Google Scholar]
  5. Dawkins S., Cavill I., Ricketts C., Worwood M. Variability of serum ferritin concentration in normal subjects. Clin Lab Haematol. 1979;1(1):41–46. doi: 10.1111/j.1365-2257.1979.tb00588.x. [DOI] [PubMed] [Google Scholar]
  6. Gropp C., Havemann K., Lehmann F. G. Carcinoembryonic antigen and ferritin in patients with lung cancer before and during therapy. Cancer. 1978 Dec;42(6):2802–2808. doi: 10.1002/1097-0142(197812)42:6<2802::aid-cncr2820420641>3.0.co;2-x. [DOI] [PubMed] [Google Scholar]
  7. HALL G. H., LAIDLAW C. D. Further experimental evidence implicating reduced ferritin as a cause of digital clubbing. Clin Sci. 1963 Feb;24:121–126. [PubMed] [Google Scholar]
  8. HALL G. H. The cause of digital clubbing; testing a new hypothesis. Lancet. 1959 Apr 11;1(7076):750–753. doi: 10.1016/s0140-6736(59)91826-4. [DOI] [PubMed] [Google Scholar]
  9. Jacobs A., Jones B., Ricketts C., Bulbrook R. D., Wang D. Y. Serum ferritin concentration in early breast cancer. Br J Cancer. 1976 Sep;34(3):286–290. doi: 10.1038/bjc.1976.164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jacobs A., Miller F., Worwood M., Beamish M. R., Wardrop C. A. Ferritin in the serum of normal subjects and patients with iron deficiency and iron overload. Br Med J. 1972 Oct 28;4(5834):206–208. doi: 10.1136/bmj.4.5834.206. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Jacobs A., Worwood M. Ferritin in serum. Clinical and biochemical implications. N Engl J Med. 1975 May 1;292(18):951–956. doi: 10.1056/NEJM197505012921805. [DOI] [PubMed] [Google Scholar]
  12. Jones B. M., Worwood M., Jacobs A. Serum ferritin in patients with cancer: determination with antibodies to HeLa cell and spleen ferritin. Clin Chim Acta. 1980 Sep 25;106(2):203–214. doi: 10.1016/0009-8981(80)90173-4. [DOI] [PubMed] [Google Scholar]
  13. Lipschitz D. A., Cook J. D., Finch C. A. A clinical evaluation of serum ferritin as an index of iron stores. N Engl J Med. 1974 May 30;290(22):1213–1216. doi: 10.1056/NEJM197405302902201. [DOI] [PubMed] [Google Scholar]
  14. Marcus D. M., Zinberg N. Isolation of ferritin from human mammary and pancreatic carcinomas by means of antibody immunoadsorbents. Arch Biochem Biophys. 1974 Jun;162(2):493–501. doi: 10.1016/0003-9861(74)90209-4. [DOI] [PubMed] [Google Scholar]
  15. Marcus D. M., Zinberg N. Measurement of serum ferritin by radioimmunoassay: results in normal individuals and patients with breast cancer. J Natl Cancer Inst. 1975 Oct;55(4):791–795. doi: 10.1093/jnci/55.4.791. [DOI] [PubMed] [Google Scholar]
  16. Niitsu Y., Urushizaki I. Measurement of serum ferritin and its clinical application. Nihon Ketsueki Gakkai Zasshi. 1978 Dec;41(6):1301–1308. [PubMed] [Google Scholar]
  17. Prieto J., Barry M., Sherlock S. Serum ferritin in patients with iron overload and with acute and chronic liver diseases. Gastroenterology. 1975 Mar;68(3):525–533. [PubMed] [Google Scholar]
  18. Racoceanu S. N., Mendlowitz M., Suck A. F., Wolf R. L., Naftchi N. E. Digital capillary blood flow in clubbing. 85 Kr studies in hereditary and acquired cases. Ann Intern Med. 1971 Dec;75(6):933–935. doi: 10.7326/0003-4819-75-6-933. [DOI] [PubMed] [Google Scholar]
  19. Sinniah D., White J. C., Omar A., Murugasu R., Iyngkaran N. Digital clubbing--a clinical sign in thalassemia. J Pediatr. 1978 Apr;92(4):597–599. doi: 10.1016/s0022-3476(78)80300-x. [DOI] [PubMed] [Google Scholar]
  20. WILSON G. M. Local circulatory changes associated with clubbing of the fingers and toes. Q J Med. 1952 Apr;21(82):201–213. [PubMed] [Google Scholar]
  21. Worwood M. Serum ferritin. CRC Crit Rev Clin Lab Sci. 1979;10(2):171–204. doi: 10.3109/10408367909147133. [DOI] [PubMed] [Google Scholar]

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