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. Author manuscript; available in PMC: 2017 Mar 1.
Published in final edited form as: Neuropharmacology. 2015 Nov 17;102:197–206. doi: 10.1016/j.neuropharm.2015.11.013

Figure 6. Effects of intra-VTA 2-hydroxysaclofen injections on CRF-induced reinstatement of extinguished cocaine seeking.

Figure 6

Data represent responding (lever presses/2-h session ±S.E.) following bilateral intra-VTA administration of CRF (500 ng/side) in rats pretreated with intra-VTA injections of vehicle or the 0.2 µg/side (Figure 6A) or 2 µg/side(Figure 6B) concentration of the GABAB receptor antagonist, 2-hydroxysaclofen (2-HS) and responding during the previous extinction (Ext) session. Intra-VTA CRF reinstated cocaine seeking following vehicle (0 µg/side) pretreatment (*P<0.05 vs. Ext) but not following pretreatment with 0.2 or 2 µg/side 2-hydroxysaclofen. Moreover, lever pressing during the reinstatement session following CRF administration was significantly lower in rats pretreated with 0.2 or 2 µg/side 2-hydroxysaclofen relative to rats pretreated with vehicle (#P<0.05 vs. 0 µg/side).