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. 1968 Jan;23(1):83–86. doi: 10.1136/thx.23.1.83

Cell kinetics and tumour formation

Cell turnover in the lungs of mice with hereditary lung tumours 1

Matthew B Divertie 1,2,3, Roy G Shorter 1,2,3, Jack L Titus 1,2,3
PMCID: PMC471737  PMID: 5637503

Abstract

Cell turnover time varies from one tissue to another but is reproducible as a hereditary characteristic for a given cell line. The present study indicates that it is prolonged in the lungs of mice congenitally predisposed to developing primary lung tumours. Primary malignant tumours occur more frequently in areas of relatively slow cell replacement in the human gastrointestinal tract than in those where cell turnover is rapid. On the basis of these observations it is suggested that postmaturity of a cell may be a significant factor in the development of neoplastic change.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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