Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1981 Nov;36(11):823–827. doi: 10.1136/thx.36.11.823

Plasma cyclic nucleotide levels in exercise-induced asthma.

J P Hartley, C J Davies, T J Charles, R D Monie, S G Nogrady, M D Winson
PMCID: PMC471822  PMID: 6277033

Abstract

It is known that sympatho-adrenal control of airways is increased in asthma since beta blockade can cause severe bronchoconstriction in asthmatic individuals. It has not been established whether an altered catecholamine response to exercise plays any part in the production of the common symptom of exercise-induced asthma (EIA). We have investigated this indirectly by measuring arterial plasma cyclic nucleotide levels in 10 subjects with EIA and five normal subjects. Cyclic AMP, which in this context reflects beta stimulation, rose significantly by 25.4% in the normal subjects during exercise, while there was no significant change during or after exercise (less than 5%) in the asthmatic subjects. Cyclic GMP rose significantly after exercise in the asthmatic subjects. Six normal subjects repeated the protocol before and after inhalation of salbutamol aerosol, 1600 microgram daily for 18 days. This did not reduce the cAMP response to exercise, and we conclude that the diminished cAMP response of the asthmatic subjects was not caused by their medication. The results may indicate either impaired catecholamine production or endogenous beta receptor hyporesponsiveness in some asthmatic subjects and this may contribute to the development of EIA.

Full text

PDF
823

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson S. D., Pojer R., Smith I. D., Temple D. Exercise-related changes in plasma levels of 15-keto-13,14-dihydro-prostaglandin F2alpha and noradrenaline in asthmatic and normal subjects. Scand J Respir Dis. 1976;57(1):41–48. [PubMed] [Google Scholar]
  2. Ball J. H., Kaminsky N. I., Hardman J. G., Broadus A. E., Sutherland E. W., Liddle G. W. Effects of catecholamines and adrenergic-blocking agents on plasma and urinary cyclic nucleotides in man. J Clin Invest. 1972 Aug;51(8):2124–2129. doi: 10.1172/JCI107019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Barboriak J. J., Sosman A. J., Fink J. N., Maksud M. G., McConnell L. H., Hamilton L. H. Metabolic changes in exercise-induced asthma. Clin Allergy. 1973 Mar;3(1):83–89. doi: 10.1111/j.1365-2222.1973.tb01312.x. [DOI] [PubMed] [Google Scholar]
  4. Chyrssanthopoulos C., Barboriak J. J., Fink J. N., Stekiel W. J., Maksud M. G. Adrenergic responses of asthmatic and normal subjects to submaximal and maximal work levels. J Allergy Clin Immunol. 1978 Jan;61(1):17–22. doi: 10.1016/0091-6749(78)90468-2. [DOI] [PubMed] [Google Scholar]
  5. Conolly M. E., Greenacre J. K. The lymphocyte beta-adrenoceptor in normal subjects and patients with bronchial asthma: the effect of different forms of treatment on receptor function. J Clin Invest. 1976 Dec;58(6):1307–1316. doi: 10.1172/JCI108586. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Griffiths J., Leung F. Y., Grzybowski S., Chan-Yeung M. M. Sequential estimation of plasma catecholamines in exercise-induced asthma. Chest. 1972 Nov;62(5):527–533. doi: 10.1378/chest.62.5.527. [DOI] [PubMed] [Google Scholar]
  7. Hartley J. P., Charles T. J., Seaton A. Betamethasone valerate inhalation and exercise-induced asthma in adults. Br J Dis Chest. 1977 Oct;71(4):253–258. [PubMed] [Google Scholar]
  8. Holgate S. T., Baldwin C. J., Tattersfield A. E. beta-adrenergic agonist resistance in normal human airways. Lancet. 1977 Aug 20;2(8034):375–377. doi: 10.1016/s0140-6736(77)90304-x. [DOI] [PubMed] [Google Scholar]
  9. Irving M. H., Britton B. J., Wood W. G., Padgham C., Carruthers M. Effects of beta adrenergic blockade on plasma catecholamines in exercise. Nature. 1974 Apr 5;248(448):531–533. doi: 10.1038/248531a0. [DOI] [PubMed] [Google Scholar]
  10. Jones R. S. Significance of effect of beta blockade on ventilatory function in normal and asthmatic subjects. Thorax. 1972 Sep;27(5):572–576. doi: 10.1136/thx.27.5.572. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. McNeill R. S., Ingram C. G. Effect of propranolol on ventilatory function. Am J Cardiol. 1966 Sep;18(3):473–475. doi: 10.1016/0002-9149(66)90072-5. [DOI] [PubMed] [Google Scholar]
  12. Miller G. J., Davies B. H., Cole T. J., Seaton A. Comparison of the bronchial response to running and cycling in asthma using an improved definition of the response to work. Thorax. 1975 Jun;30(3):306–311. doi: 10.1136/thx.30.3.306. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Murad F. Clinical studies and applications of cyclic nucleotides. Adv Cyclic Nucleotide Res. 1973;3:355–383. [PubMed] [Google Scholar]
  14. Platshon L. F., Kaliner M. The effects of the immunologic release of histamine upon human lung cyclic nucleotide levels and prostaglandin generation. J Clin Invest. 1978 Dec;62(6):1113–1121. doi: 10.1172/JCI109230. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Siddle K., Davies C. J., Shetty K. J., Elkeles R. S. The effect of insulin on adenosine 3':5'-monophosphate and guanosine 3':5'-monophosphate concentrations in human plasma. Clin Sci Mol Med. 1976 Jun;50(6):487–491. doi: 10.1042/cs0500487. [DOI] [PubMed] [Google Scholar]
  16. Siddle K., Kane-Maguire B., Campbell A. K. The effects of glucagon and insulin on adenosine 3':5'-cyclic monophosphate concentrations in an organ culture of mature rat liver. Biochem J. 1973 Apr;132(4):765–773. doi: 10.1042/bj1320765. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. VENDSALU A. Studies on adrenaline and noradrenaline in human plasma. Acta Physiol Scand Suppl. 1960;49(173):1–123. [PubMed] [Google Scholar]
  18. VON EULER U., FRANKSSON C., HELLSTROM J. Adrenaline and noradrenaline output in urine after unilateral and bilateral adrenalectomy in man. Acta Physiol Scand. 1954 Jun 21;31(1):1–5. doi: 10.1111/j.1748-1716.1954.tb01107.x. [DOI] [PubMed] [Google Scholar]
  19. Wehmann R. E., Blonde L., Steiner A. L. Sources of cyclic nucleotides in plasma. J Clin Invest. 1974 Jan;53(1):173–179. doi: 10.1172/JCI107535. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES