Table 1.
Sequential temperature measurementsa
| Time-points | ||||||||
|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | ||
| Experiment/Groupb | N | Pre-surgery | End of HI | 15 min post-HI | 60 min post-HI | 75 min post-HI | 90 min post-HI | 240 min post-HI |
| DHA+HT | 36 | 33.1 ±0.8 | 35.0 ±0.6 | 35.2 ±0.5 | 36.0 ±0.4 | 31.3 ±0.8 | 31.2 ±0.7 | 32.2 ±1.0 |
| ALB+HT | 36 | 33.3 ±0.8 | 34.8 ±0.7 | 35.3 ±0.6 | 36.1 ±0.3 | 31.3 ±0.8 | 31.1 ±0.6 | 32.2 ±1.1 |
HI: hypoxia-ischemia; ALB: 25%albumin; DHA: docosahexaenoic acid; HT: hypothermia.
a
: temperatures (°C) are expressed as mean ±SD.
b
: All animals underwent HI lesioning (see Methods); 15 min after the end of HI all received injections of DHA 2.5 mg/kg (in 25% albumin) or an equivalent volume of 25% albumin. All animals underwent HT (30°C incubator for 3h, beginning at 1 h after HI); time-point 4 corresponds with the beginning of HT and time-point 7 is at the end of HT. Data presented includes 3 litters with outcome to P14 and 3 litters with outcome to P28.