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. Author manuscript; available in PMC: 2016 Jan 21.
Published in final edited form as: Oncogene. 2014 Sep 8;34(27):3536–3546. doi: 10.1038/onc.2014.281

Figure 6.

Figure 6

YAP/TAZ activation is important for vGPCR-induced tumorigenesis. (a, b) YAP/TAZ are essential for vGPCR-induced anchorage independent growth. The stable SVEC cells described in Figure 5a were tested for anchorage independent growth. Cells were seeded at 3 X 104 cells/well in 0.4% soft agar medium with hygromycin and puromycin. After twenty days, colonies were visualized with crystal violet staining and quantified. (c, d) YAP/TAZ are important for vGPCR-induced tumorigenesis. 1 × 106 SVEC cells were injected subcutaneously into the flanks of nude mice. Tumors were harvested 5 weeks after injection and weighed.