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. 1970 Nov;25(6):732–736. doi: 10.1136/thx.25.6.732

Effect of tolazoline hydrochloride on sputum viscosity in cystic fibrosis

Elizabeth A Feather 1,2, George Russell 1,2
PMCID: PMC472217  PMID: 5494682

Abstract

Comparisons have been made between the effects of autonomic dysfunction and the pathophysiological changes in the exocrine secretions from patients with cystic fibrosis (Roberts, 1959). Cotton (1966) found that administration of tolazoline hydrochloride (an alpha-adrenergic blocker) to patients with cor pulmonale in the terminal stages of cystic fibrosis was associated with an improvement in the results of their lung function tests. This effect might have been due to an alteration of the abnormal viscosity of the bronchial mucus mediated via the autonomic nervous system, thus permitting easier expectoration. Measurement, by means of a Ferranti-Shirely cone and plate viscometer, of several different aspects of sputum viscosity is described. Tolazoline hydrochloride, administered to five patients with cystic fibrosis, was shown not to differ significantly from a placebo in its effect on sputum viscosity and dynamic lung volumes. We could not relate the improved lung function seen in Cotton's series to an autonomic effect of the drug on the physical properties of bronchial mucus in this condition.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BERGSTRAND H. Fibrocystic disease of the pancreas, a disorder of the autonomic nervous system. Acta Paediatr. 1951 Jul;40(4):349–359. doi: 10.1111/j.1651-2227.1951.tb15799.x. [DOI] [PubMed] [Google Scholar]
  2. BLANSHARD G. The viscometry of sputum. Arch Middx Hosp. 1955 Oct;5(4):222–241. [PubMed] [Google Scholar]
  3. Dippy J. E., Davis S. S. Rheological assessment of mucolytic agents on sputum of chronic bronchitics. Thorax. 1969 Nov;24(6):707–713. doi: 10.1136/thx.24.6.707. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. GOLDRING R. M., FISHMAN A. P., TURINO G. M., COHEN H. I., DENNING C. R., ANDERSEN D. H. PULMONARY HYPERTENSION AND COR PULMONALE IN CYSTIC FIBROSIS OF THE PANCREAS. J Pediatr. 1964 Oct;65:501–524. doi: 10.1016/s0022-3476(64)80286-9. [DOI] [PubMed] [Google Scholar]
  5. Grimson K. S., Reardon M. J., Marzoni F. A., Hendrix J. P. The Effects of Priscol (2 Benzyl-4, 5 Imidazoline HCl) on Peripheral Vascular Diseases, Hypertension and Circulation in Patients. Ann Surg. 1948 May;127(5):968–990. [PMC free article] [PubMed] [Google Scholar]
  6. KINISON G. L., BREEDEN C. J., CARMACK R. M., BALLARD B. M., MEL P. J., HEMINGWAY A. REFLEX CHANGES IN HEART RATE AND VENTILATION INDUCED BY CENTRAL BLOOD PRESSURE CHANGES. Am J Physiol. 1965 Jun;208:1222–1230. doi: 10.1152/ajplegacy.1965.208.6.1222. [DOI] [PubMed] [Google Scholar]
  7. Kelminson L. L., Cotton E. K., Vogel J. H. The reversibility of pulmonary hypertension in patients with cystic fibrosis. Observations on the effects of tolazoline hydrochloride. Pediatrics. 1967 Jan;39(1):24–35. [PubMed] [Google Scholar]
  8. Lunn J. E. Respiratory measurements of 3,556 Sheffield schoolchildren. Br J Prev Soc Med. 1965 Jul;19(3):115–122. doi: 10.1136/jech.19.3.115. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Mearns M. B. Simple tests of ventilatory capacity in children with cystic fibrosis. I. Clinical and radiological findings in 85 patients. II. Three-year follow-up on 50 patients. Arch Dis Child. 1968 Oct;43(231):528–539. doi: 10.1136/adc.43.231.528. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. ROBERTS G. B. Fundamental defect in fibrocystic disease of the pancreas. Lancet. 1959 Nov 28;2(7109):964–965. doi: 10.1016/s0140-6736(59)91607-1. [DOI] [PubMed] [Google Scholar]
  11. ROYCE S. W. Cor pulmonale in infancy and early childhood; report on 34 patients, with special reference to the occurrence of pulmonary heart disease in cystic fibrosis of the pancreas. Pediatrics. 1951 Aug;8(2):255–274. [PubMed] [Google Scholar]
  12. Rubin L. S., Barbero G. J., Chernick W. Pupillary dysfunction as a concomitant of cystic fibrosis. Pediatrics. 1966 Nov;38(5):865–873. [PubMed] [Google Scholar]
  13. SINGH I., KHANNA P. K., LAL M., HOON R. S., RAO B. D. HIGH-ALTITUDE PULMONARY HYPERTENSION. Lancet. 1965 Jul 24;2(7404):146–150. doi: 10.1016/s0140-6736(65)90229-1. [DOI] [PubMed] [Google Scholar]
  14. STRANG L. B. The ventilatory capacity of normal children. Thorax. 1959 Dec;14:305–310. doi: 10.1136/thx.14.4.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. WELLS R. E., Jr, DENTON R., MERRILL E. W. Measurement of viscosity of biologic fluids by cone plate viscometer. J Lab Clin Med. 1961 Apr;57:646–656. [PubMed] [Google Scholar]

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