Table 1.
Improvements over starting models for human submissions. Average improvements are given using four different measures, and the sum of Z-scores relative to other group predictions are in parentheses. Summed Z-scores are calculated using -2.0 for the minimum value, and positive values are better for all measures. Analysis with minimum Z-score = 0.0 is provided in Supplementary Table S1.
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| Target category | Num. Targets | GDT-HA (%) | Sphere Grinder (%) | Cα RMSD (Å) | MolProbity | |
| iGDT-HA >= 501) | 242) | Model1 | +1.0 (+15.1) | +3.8 (+23.3) | -0.50 (+26.4) | -1.1 (+19.7) |
| Top5 | +3.9 (+35.0) | +7.2 (+46.5) | -0.84 (+45.4) | -1.4 (+27.3) | ||
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| iGDT-HA < 503) | 12 | Model1 | -3.9 (-11.6) | -1.1 (+2.3) | +1.31 (-6.6) | -1.3 (+10.0) |
| Top5 | +2.0 (+6.4) | +4.3 (+21.4) | +0.27 (+1.5) | -1.6 (+15.0) | ||
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| Overall | 36 | Model1 | -0.6 (+3.5) | +2.2 (+25.6) | +0.10 (+19.8) | -1.2 (+29.7) |
| Top5 | +3.3 (+41.4) | +6.3 (+67.9) | -0.47 (+46.9) | -1.5 (+42.3) | ||
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1)
Targets with starting GDT-HA higher than or equal to 50.0, to which high-resolution strategy is applied.
2)
TR769 is not submitted as the target protein is engineered from Baker group.
3)
Targets with starting GDT-HA lower than 50.0, to which low-resolution strategy is applied.