Abstract
Accumulated evidence indicates that fresh aortic valve homografts function longer than preserved grafts. Thus it becomes important to assess the viability of fresh homografts on a quantitative basis. Recently, we have used autoradiography in addition to tissue culture to determine the viability of fresh aortic and pulmonary valve homografts. The uptake of thymidine was gradually reduced to 50% after 18 days of preservation in a balanced salt solution with antibiotics and the uptake was reduced to 21% in 63 days. We think that a nutrient medium is necessary if longer viability is to be obtained.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bahnson H. T., Hardesty R. L., Baker L. D., Jr, Brooks D. H., Gall D. A. Fabrication and evaluation of tissue leaflets for aortic and mitral valve replacement. Ann Surg. 1970 Jun;171(6):939–947. doi: 10.1097/00000658-197006010-00015. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barratt-Boyes B. G., Roche A. H. A review of aortic valve homografts over a six and one-half year period. Ann Surg. 1969 Sep;170(3):483–492. doi: 10.1097/00000658-196909010-00016. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Barratt-Boyes B. G., Roche A. H., Brandt P. W., Smith J. C., Lowe J. B. Aortic homograft valve replacement. A long-term follow-up of an initial series of 101 patients. Circulation. 1969 Dec;40(6):763–775. [PubMed] [Google Scholar]
- Smith J. C. The pathology of human aortic valve homografts. Thorax. 1967 Mar;22(2):114–138. doi: 10.1136/thx.22.2.114. [DOI] [PMC free article] [PubMed] [Google Scholar]