Abstract
BACKGROUND: In several longitudinal studies changes in body mass and in forced expiratory volume in one second (FEV1) have been found to be negatively correlated. This paper tests the hypothesis that failure to allow for the association can lead to error in the interpretation of longitudinal measurements of ventilatory capacity. METHODS: Male shipyard workers (n = 1005) were assessed on two occasions with an average interval between measurements of 6.9 years. A respiratory symptoms questionnaire, detailed anthropometric measurements, and dynamic spirometric tests were undertaken. Multiple regression analysis was used to identify variables which contributed to the changes in lung function. RESULTS: After allowing for age and growth in stature, a change in body mass of 1 kg was, on average, associated with a mean (SE) converse change in FEV1 of 17.6 (2.0) ml, and in forced vital capacity (FVC) of 21.1 (2.5) ml. Neglect of changes in body mass (which in this context reflected changes in body fat) led to underestimation of the longitudinal decline in FEV1 with age and failure to detect significant improvements in FEV1, both in smokers following discontinuation of smoking and in shipyard welders and caulker/burners as a consequence of leaving their employment. The estimated peak ages and associated peak levels of the indices were found to differ, depending on whether or not they were expressed at constant body mass. CONCLUSIONS: Neglect of changes in body mass can lead to erroneous conclusions being drawn from longitudinal measurements of FEV1.
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Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ashwell M., Cole T. J., Dixon A. K. Obesity: new insight into the anthropometric classification of fat distribution shown by computed tomography. Br Med J (Clin Res Ed) 1985 Jun 8;290(6483):1692–1694. doi: 10.1136/bmj.290.6483.1692. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bande J., Clément J., Van de Woestijne K. P. The influence of smoking habits and body weight on vital capacity and FEV1 in male Air Force personnel: a longitudinal and cross-sectional analysis. Am Rev Respir Dis. 1980 Nov;122(5):781–790. doi: 10.1164/arrd.1980.122.5.781. [DOI] [PubMed] [Google Scholar]
- Borkan G. A., Sparrow D., Wisniewski C., Vokonas P. S. Body weight and coronary disease risk: patterns of risk factor change associated with long-term weight change. The Normative Aging Study. Am J Epidemiol. 1986 Sep;124(3):410–419. doi: 10.1093/oxfordjournals.aje.a114411. [DOI] [PubMed] [Google Scholar]
- Burrows B., Lebowitz M. D., Camilli A. E., Knudson R. J. Longitudinal changes in forced expiratory volume in one second in adults. Methodologic considerations and findings in healthy nonsmokers. Am Rev Respir Dis. 1986 Jun;133(6):974–980. doi: 10.1164/arrd.1986.133.6.974. [DOI] [PubMed] [Google Scholar]
- Chen Y., Horne S. L., Dosman J. A. Body weight and weight gain related to pulmonary function decline in adults: a six year follow up study. Thorax. 1993 Apr;48(4):375–380. doi: 10.1136/thx.48.4.375. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chinn D. J., Cotes J. E., el Gamal F. M., Wollaston J. F. Respiratory health of young shipyard welders and other tradesmen studied cross sectionally and longitudinally. Occup Environ Med. 1995 Jan;52(1):33–42. doi: 10.1136/oem.52.1.33. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chinn D. J., Stevenson I. C., Cotes J. E. Longitudinal respiratory survey of shipyard workers: effects of trade and atopic status. Br J Ind Med. 1990 Feb;47(2):83–90. doi: 10.1136/oem.47.2.83. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cotes J. E., Dabbs J. M., Hall A. M., Heywood C., Laurence K. M. Sitting height, fat-free mass and body fat as reference variables for lung function in healthy British children: comparison with stature. Ann Hum Biol. 1979 Jul-Aug;6(4):307–314. doi: 10.1080/03014467900003691. [DOI] [PubMed] [Google Scholar]
- Cotes J. E., Feinmann E. L., Male V. J., Rennie F. S., Wickham C. A. Respiratory symptoms and impairment in shipyard welders and caulker/burners. Br J Ind Med. 1989 May;46(5):292–301. doi: 10.1136/oem.46.5.292. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cotes J. E., Gilson J. C. Effects of inactivity, weight gain and antitubercular chemotherapy upon lung function in working coal-miners. Ann Occup Hyg. 1967 Oct;10(4):327–335. doi: 10.1093/annhyg/10.4.327. [DOI] [PubMed] [Google Scholar]
- Dockery D. W., Ware J. H., Ferris B. G., Jr, Glicksberg D. S., Fay M. E., Spiro A., 3rd, Speizer F. E. Distribution of forced expiratory volume in one second and forced vital capacity in healthy, white, adult never-smokers in six U.S. cities. Am Rev Respir Dis. 1985 Apr;131(4):511–520. doi: 10.1164/arrd.1985.131.4.511. [DOI] [PubMed] [Google Scholar]
- Durnin J. V., Womersley J. Body fat assessed from total body density and its estimation from skinfold thickness: measurements on 481 men and women aged from 16 to 72 years. Br J Nutr. 1974 Jul;32(1):77–97. doi: 10.1079/bjn19740060. [DOI] [PubMed] [Google Scholar]
- Krotkiewski M., Björntorp P., Sjöström L., Smith U. Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution. J Clin Invest. 1983 Sep;72(3):1150–1162. doi: 10.1172/JCI111040. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McDermott M., McDermott T. J. Digital incremental techniques applied to spirometry. Proc R Soc Med. 1977 Mar;70(3):169–171. doi: 10.1177/003591577707000310. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Rolland-Cachera M. F., Cole T. J., Sempé M., Tichet J., Rossignol C., Charraud A. Body Mass Index variations: centiles from birth to 87 years. Eur J Clin Nutr. 1991 Jan;45(1):13–21. [PubMed] [Google Scholar]
- Schoenberg J. B., Beck G. J., Bouhuys A. Growth and decay of pulmonary function in healthy blacks and whites. Respir Physiol. 1978 Jun;33(3):367–393. doi: 10.1016/0034-5687(78)90063-4. [DOI] [PubMed] [Google Scholar]
- Weller J. J., el-Gamal F. M., Parker L., Reed J. W., Cotes J. E. Indirect estimation of maximal oxygen uptake for study of working populations. Br J Ind Med. 1988 Aug;45(8):532–537. doi: 10.1136/oem.45.8.532. [DOI] [PMC free article] [PubMed] [Google Scholar]