Abstract
A patient with an aortic arch aneurysm, who was submitted to resection and replacement by a prosthetic graft during a 36-minute period of cerebral arterial occlusion at 20° C, and who subsequently died of ischaemic brain damage, is reported.
Current methods for protection of the central nervous system from ischaemic damage during operations of this type are reviewed. It is considered that total body perfusion, including all arteries which supply the circle of Willis, with hypothermia as low as 20° C, will provide the safest background to a successful operation.
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- Belsey R. H., Dowlatshahi K., Keen G., Skinner D. B. Profound hypothermia in cardiac surgery. J Thorac Cardiovasc Surg. 1968 Oct;56(4):497–509. [PubMed] [Google Scholar]
- CLOWES G. H., Jr, NEVILLE W. E., SABGA G., SHIBOTA Y. The relationship of oxygen consumption, perfusion rate, and temperature to the acidosis associated with cardiopulmonary circulatory bypass. Surgery. 1958 Jul;44(1):220–239. [PubMed] [Google Scholar]
- Connolly J. E., Roy A., Guernsey J. M., Stemmer E. A. Bloodless surgery by means of profound hypothermia and circulatory arrest. Effect on brain and heart. Ann Surg. 1965 Oct;162(4):724–737. doi: 10.1097/00000658-196510000-00014. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Crawford E. S., Fenstermacher J. M., Richardson W., Sandiford F. Reappraisal of adjuncts to avoid ischemia in the treatment of thoracic aortic aneurysms. Surgery. 1970 Jan;67(1):182–196. [PubMed] [Google Scholar]
- DE BAKEY M. E., CRAWFORD E. S., COOLEY D. A., MORRIS G. C., Jr Successful resection of fusiform aneurysm of aortic arch with replacement by homograft. Surg Gynecol Obstet. 1957 Dec;105(6):657–664. [PubMed] [Google Scholar]
- DREW C. E., ANDERSON I. M. Profound hypothermia in cardiac surgery: report of three cases. Lancet. 1959 Apr 11;1(7076):748–750. doi: 10.1016/s0140-6736(59)91825-2. [DOI] [PubMed] [Google Scholar]
- Edmunds L. H., Folkman J., Snodgress A. B., Brown R. B. Prevention of Brain Damage During Profound Hypothermia and Circulatory Arrest. Ann Surg. 1963 Apr;157(4):637–649. doi: 10.1097/00000658-196304000-00022. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GOLLAN F., PHILLIPS R., Jr, GRACE J. T., JONES R. M. Open left heart surgery in dogs during hypothermic asystole with and without extracorporeal circulation. J Thorac Surg. 1955 Nov;30(5):626–630. [PubMed] [Google Scholar]
- GONSKI A., JOHNSTON J. B., HERCUS V. M., ROLLISON R. A., NIELD J. PROFOUND HYPOTHERMIA FOR INTRACRANIAL SURGERY: CASE REPORT. Med J Aust. 1964 Feb 29;1:318–320. doi: 10.5694/j.1326-5377.1964.tb134076.x. [DOI] [PubMed] [Google Scholar]
- Gye R., Segelov J., Nicks R., Cartmill T., Bookallil M., Clarke B. Control of the cerebral circulation in the surgical treatment of ruptured intracranial aneurysms. Med J Aust. 1969 Feb 8;1(6):263–268. doi: 10.5694/j.1326-5377.1969.tb92121.x. [DOI] [PubMed] [Google Scholar]
- HARDIN C. A., BATCHELDER T. L., SCHAFER P. W. The temporary use of polyethylene shunts in the resection and homologous graft replacement of the aortic arch in the dog. Surgery. 1952 Aug;32(2):219–225. [PubMed] [Google Scholar]
- Johnston J. B., Ushiro C., Finley K. H., Gerbode F. Profound hypothermia with prolonged circulatory arrest. An experimental study. Thorax. 1966 Sep;21(5):391–400. doi: 10.1136/thx.21.5.391. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KAMEYA S., OZ M., NEVILLE W. E., CLOWES G. H., Jr A study of oxygen consumption during profound hypothermia induced by perfusion of the entire body. Surg Forum. 1960;11:190–191. [PubMed] [Google Scholar]
- KIRKLIN J. W., DEVLOO R. A. Hypothermic perfusion and circulatory arrest for surgical correction of tetralogy of Fallot with previously constructed Potts' anastomosis. Dis Chest. 1961 Jan;39:87–91. doi: 10.1378/chest.39.1.87. [DOI] [PubMed] [Google Scholar]
- Lillehei C. W., Todd D. B., Jr, Levy M. J., Ellis R. J. Partial cardiopulmonary bypass, hypothermia, and total circulatory arrest. A lifesaving technique for ruptured mycotic aortic aneurysms, ruptured left ventricle, and other complicated cardiac pathology. J Thorac Cardiovasc Surg. 1969 Oct;58(4):530–544. [PubMed] [Google Scholar]
- MULLER W. H., Jr, WARREN W. D., BLANTON F. S., Jr A method for resection of aortic arch aneurysms. Ann Surg. 1960 Feb;151:225–230. doi: 10.1097/00000658-196002000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pearce C. W., Weichert R. F., 3rd, del Real R. E. Aneurysms of aortic arch. Simplified technique for excision and prosthetic replacement. J Thorac Cardiovasc Surg. 1969 Dec;58(6):886–890. [PubMed] [Google Scholar]
- STRANAHAN A., ALLEY R. D., SEWELL W. H., KAUSEL H. W. Aortic arch resection and grafting for aneurysms employing an external shunt. J Thorac Surg. 1955 Jan;29(1):54–65. [PubMed] [Google Scholar]
- TREDE M., CHIR B., FOOTE A. V., MALONEY J. V., Jr Pathophysiologic aspects of profound hypothermia with extracorporeal circulation. Ann Surg. 1961 Aug;154:210–224. doi: 10.1097/00000658-196108000-00005. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WHITE R. J., DONALD D. E. Selective hypothermic perfusion and circulatory arrest. Experiments in the dog brain. Arch Surg. 1962 Mar;84:292–300. doi: 10.1001/archsurg.1962.01300210026006. [DOI] [PubMed] [Google Scholar]





