Skip to main content
NCBI home page
Thorax logoLink to Thorax
. 1996 Jan;51(1):82–86. doi: 10.1136/thx.51.1.82

Peritoneal ventilation in rabbits: augmentation of gas exchange with cisapride.

J Barr 1, G Lushkov 1, S Strauss 1, S Gurevitch 1, E Lahat 1, T Bistritzer 1, B Klin 1, G Eshel 1
PMCID: PMC472806  PMID: 8658376

Abstract

BACKGROUND: Peritoneal ventilation has been shown to be effective in achieving extrapulmonary oxygenation and carbon dioxide elimination in an animal model of severe adult respiratory distress syndrome (ARDS). Cisapride is a "prokinetic" agent (increases gastric emptying), that may increase the splanchnic circulation and thus favourably affect gas exchange in peritoneal ventilation. METHODS: Using Doppler ultrasound the effect of cisapride on the portal venous circulation was examined in eight spontaneously breathing rabbits and the effect of cisapride on gas exchange in five rabbits spontaneously breathing room air was compared with that of a control group who did not receive cisapride. Its effect on gas exchange in five rabbits with ARDS being treated with mechanical lung and peritoneal ventilation was compared with that of a control group, and its effect on gas exchange in five rabbits with ARDS treated with conventional ventilation was also compared with that of a control group. RESULTS: Enteral administration of cisapride increased portal venous blood velocity, as measured ultrasonographically, by a mean of 188% one hour after receiving the drug. In rabbits with ARDS being treated with both peritoneal ventilation and mechanical ventilation to the lungs, those receiving cisapride had arterial oxygen tensions 1.5-3 times that of controls. Cisapride had no effect on arterial blood gas tensions in rabbits who were spontaneously breathing room air, nor in rabbits with ARDS who received only conventional mechanical lung ventilation. CONCLUSIONS: Cisapride increases arterial oxygenation in rabbits with severe ARDS treated with peritoneal ventilation, probably due to its ability to increase splanchnic circulation. It should be considered as an adjuvant medication to peritoneal ventilation.

Full text

PDF
82

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Awad J. A., Brassard A., Caron W. M. Intraperitoneal oxygenation. An experimental study in dogs. Int Surg. 1970 Mar;53(3):162–166. [PubMed] [Google Scholar]
  2. Barr J., Livne A., Lushkov G., Vinograd I., Efrati Y., Ballin A., Lahat E., Eshel G. Peritoneal ventilation: an animal model of extrapulmonary ventilation in experimental adult respiratory distress syndrome. Pediatr Res. 1994 Jun;35(6):682–684. doi: 10.1203/00006450-199406000-00012. [DOI] [PubMed] [Google Scholar]
  3. Bilge F. B., Bedenbaugh P. H., 3rd, von Recum A. F. Peritoneal oxygenation. A feasibility analysis. Biomater Artif Cells Artif Organs. 1989;17(4):413–427. doi: 10.3109/10731198909118856. [DOI] [PubMed] [Google Scholar]
  4. Faithfull N. S., Klein J., van der Zee H. T., Salt P. J. Whole body oxygenation using intraperitoneal perfusion of fluorocarbons. Br J Anaesth. 1984 Aug;56(8):867–872. doi: 10.1093/bja/56.8.867. [DOI] [PubMed] [Google Scholar]
  5. Huber G. L., Edmunds L. H., Jr, Finley T. N. Acute effect of saline lung washing on pulmonary mechanics and morphology. Surg Forum. 1966;17:113–114. [PubMed] [Google Scholar]
  6. Klein J., Faithfull N. S., Salt P. J., Trouwborst A. Transperitoneal oxygenation with fluorocarbons. Anesth Analg. 1986 Jul;65(7):734–738. [PubMed] [Google Scholar]
  7. Kuckelt W., Dauberschmidt R., Bender V., Hieronymi U., Mrochen H., Winsel K., Meyer M. Experimental investigations in adult respiratory distress syndrome (ARDS). Repeated pulmonary lavage in LEWE-mini-pigs. I. Pulmonary mechanics, gas exchange, and pulmonary hemodynamics. Exp Pathol. 1981;20(2):88–104. [PubMed] [Google Scholar]
  8. Lachmann B., Robertson B., Vogel J. In vivo lung lavage as an experimental model of the respiratory distress syndrome. Acta Anaesthesiol Scand. 1980 Jun;24(3):231–236. doi: 10.1111/j.1399-6576.1980.tb01541.x. [DOI] [PubMed] [Google Scholar]
  9. Morris A. H., Wallace C. J., Menlove R. L., Clemmer T. P., Orme J. F., Jr, Weaver L. K., Dean N. C., Thomas F., East T. D., Pace N. L. Randomized clinical trial of pressure-controlled inverse ratio ventilation and extracorporeal CO2 removal for adult respiratory distress syndrome. Am J Respir Crit Care Med. 1994 Feb;149(2 Pt 1):295–305. doi: 10.1164/ajrccm.149.2.8306022. [DOI] [PubMed] [Google Scholar]
  10. Morton A., Dalton H., Kochanek P., Janosky J., Thompson A. Extracorporeal membrane oxygenation for pediatric respiratory failure: five-year experience at the University of Pittsburgh. Crit Care Med. 1994 Oct;22(10):1659–1667. [PubMed] [Google Scholar]
  11. Sanford T. D., Colby E. D. Effect of xylazine and ketamine on blood pressure, heart rate and respiratory rate in rabbits. Lab Anim Sci. 1980 Jun;30(3):519–523. [PubMed] [Google Scholar]
  12. White G. L., Holmes D. D. A comparison of ketamine and the combination ketamine-xylazine for effective surgical anesthesia in the rabbit. Lab Anim Sci. 1976 Oct;26(5):804–806. [PubMed] [Google Scholar]
  13. Yokoyama T., Kitazawa T., Ishii A., Ogihara T., Sato N., Karasawa A. Protective effect of cisapride against indomethacin-induced obstruction of the gastric mucosal hemodynamics in rats. Jpn J Pharmacol. 1994 Jun;65(2):171–173. doi: 10.1254/jjp.65.171. [DOI] [PubMed] [Google Scholar]

Articles from Thorax are provided here courtesy of BMJ Publishing Group

RESOURCES