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. 1965 Mar;18(2):157–163. doi: 10.1136/jcp.18.2.157

Renal involvement in active `juvenile' cirrhosis

Homero Silva 1,2, Elizabeth W Hall 1,2, Kenneth R Hill 1,2, Stanley Shaldon 1,2, Sheila Sherlock 1,2
PMCID: PMC472857  PMID: 14279121

Abstract

Twelve patients with active `juvenile' cirrhosis (active chronic hepatitis, `lupoid' hepatitis) and six subjects with other types of portal or postnecrotic cirrhosis were submitted to percutaneous renal biopsy. In addition, renal function was assessed in all patients by measurement of the 24-hour endogenous creatinine clearance, maximal urinary osmolality after deprivation of water, 24-hour urinary protein excretion, and routine urine analysis.

Renal function was not significantly abnormal in either group of patients, but seven of the 12 patients with active `juvenile' cirrhosis showed mild histological changes on renal biopsy. These changes are very similar to the lesions described in early `lupus nephritis'.

The significance of these findings in relation to the aetiology of active `juvenile' cirrhosis is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARONSON A. R., MONTGOMERY M. M. Chronic liver disease with a "lupus erythematosus-like syndrome". Arch Intern Med. 1959 Oct;104:544–552. doi: 10.1001/archinte.1959.00270100030006. [DOI] [PubMed] [Google Scholar]
  2. BARTHOLOMEW L. G., CAIN J. C., BAGGENSTOSS A. H., HAGEDORN A. B. Further obervations on hepatitis and cirrhosis in young women with positive clot tests for lupus erythematousus. Gastroenterology. 1960 Dec;39:730–736. [PubMed] [Google Scholar]
  3. BARTHOLOMEW L. G., HAGEDORN A. B., CAIN J. C., BAGGENSTOSS A. H. Hepatitis and cirrhosis in women with positive clot tests for lupus erythematosus. N Engl J Med. 1958 Nov 13;259(20):947–956. doi: 10.1056/NEJM195811132592001. [DOI] [PubMed] [Google Scholar]
  4. BEARN A. G., KUNKEL H. G., SLATER R. J. The problem of chronic liver disease in young women. Am J Med. 1956 Jul;21(1):3–15. doi: 10.1016/0002-9343(56)90003-1. [DOI] [PubMed] [Google Scholar]
  5. BLOODWORTH J. M., Jr, SOMMERS S. C. "Cirrhotic glomerulosclerosis," a renal lesion associated with hepatic cirrhosis. Lab Invest. 1959 Sep-Oct;8:962–978. [PubMed] [Google Scholar]
  6. COWLING D. C., MACKAY I. R., TAFT L. I. Lupoid hepatitis. Lancet. 1956 Dec 29;271(6957):1323–1326. doi: 10.1016/s0140-6736(56)91483-0. [DOI] [PubMed] [Google Scholar]
  7. CROWSON C. N., MORE R. H. Glomerulotubular nephrosis correlated with hepatic lesions. II. Incidence and morphology of associated kidney and liver lesions in human autopsy material. AMA Arch Pathol. 1955 Jul;60(1):73–84. [PubMed] [Google Scholar]
  8. FISHER E. R., HELLSTROM H. R. The membranous and proliferative glomerulonephritis of hepatic cirrhosis. Am J Clin Pathol. 1959 Jul;32(1):48–55. doi: 10.1093/ajcp/32.1.48. [DOI] [PubMed] [Google Scholar]
  9. HARVEY A. M., SHULMAN L. E., TUMULTY P. A., CONLEY C. L., SCHOENRICH E. H. Systemic lupus erythematosus: review of the literature and clinical analysis of 138 cases. Medicine (Baltimore) 1954 Dec;33(4):291–437. [PubMed] [Google Scholar]
  10. HELLER P., ZIMMERMAN H. J., ROZENGVAIG S., SINGER K. The L.E.-cell phenomenon in chronic hepatic disease. N Engl J Med. 1956 Jun 21;254(25):1160–1165. doi: 10.1056/NEJM195606212542503. [DOI] [PubMed] [Google Scholar]
  11. JONES W. A., CASTLEMAN B. Liver disease in young women with hyperglobulinemia. Am J Pathol. 1962 Mar;40:315–329. [PMC free article] [PubMed] [Google Scholar]
  12. JOSKE R. A., KING W. E. The L.E.-cell phenomenon in active chronic viral hepatitis. Lancet. 1955 Sep 3;269(6888):477–480. doi: 10.1016/s0140-6736(55)93331-6. [DOI] [PubMed] [Google Scholar]
  13. KARK R. M., MUEHRCKE R. C. Biopsy of kidney in prone position. Lancet. 1954 May 22;266(6821):1047–1049. doi: 10.1016/s0140-6736(54)91618-9. [DOI] [PubMed] [Google Scholar]
  14. LENDRUM A. C., FRASER D. S., SLIDDERS W., HENDERSON R. Studies on the character and staining of fibrin. J Clin Pathol. 1962 Sep;15:401–413. doi: 10.1136/jcp.15.5.401. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. MUEHRCKE R. C., KARK R. M., PIRANI C. L., POLLAK V. E. Lupus nephritis: a clinical and pathologic study based on renal biopsies. Medicine (Baltimore) 1957 Feb;36(1):1–145. [PubMed] [Google Scholar]
  16. PAGE A. R., GOOD R. A. Plasma-cell hepatitis, with special attention to steroid therapy. AMA J Dis Child. 1960 Mar;99:288–314. doi: 10.1001/archpedi.1960.02070030290006. [DOI] [PubMed] [Google Scholar]
  17. PATEK A. J., Jr, SEEGAL D., BEVANS M. The coexistence of cirrhosis of the liver and glomerulonephritis; report of 14 cases. Am J Med Sci. 1951 Jan;221(1):77–85. doi: 10.1097/00000441-195101000-00011. [DOI] [PubMed] [Google Scholar]
  18. READ A. E., SHERLOCK S., HARRISON C. V. ACTIVE 'JUVENILE' CIRRHOSIS CONSIDERED AS PART OF A SYSTEMIC DISEASE AND THE EFFECT OF CORTICOSTEROID THERAPY. Gut. 1963 Dec;4:378–393. doi: 10.1136/gut.4.4.378. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. WILLOCX R. G., ISSELBACHER K. J. Chronic liver disease in young people. Clinical features and course in thirty-three patients. Am J Med. 1961 Feb;30:185–195. doi: 10.1016/0002-9343(61)90090-0. [DOI] [PubMed] [Google Scholar]

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