Table 5.
Time Course for Trials of Statins | No. of Patients Responding | Time to Onset or Recovery (wks)
|
||
---|---|---|---|---|
Median | Mean ± SD | Rangea | ||
First trials resulting in MAEsb | ||||
Time to MAE onset after starting the statin | 301 | 14 | 55 ± 95 | 0.14–520 |
Time to first noted recovery after statin discontinuation | 189 | 2 | 8 ± 16 | 0.14–144 |
Time to maximal recovery after statin discontinuation | 149 | 8 | 29 ± 64 | 0.14–624 |
Time to complete recovery after statin discontinuation (confined to those reporting complete recovery) | 70 | 4 | 14 ± 19 | 0.14–96 |
Index vs rechallenge trial resulting in MAEsb | ||||
Time to onset, first occurrence, in those with rechallenge datac | 98 | 12 | 43 ± 78 | 0.14–520 |
Time to onset after first rechallengec | 98 | 2 | 15 ± 42 | 0.14–286 |
Time to recovery, first occurrence, in those with rechallenge datad | 56 | 2 | 6 ± 11 | 0.14–48 |
Time to recovery after first rechallenged | 56 | 2 | 12 ± 39 | 0.14–286 |
Rechallenge trials resulting in MAEs | ||||
Time to first noted recovery after first statin rechallenge discontinued | 72 | 2 | 8 ± 18 | 0.14–104 |
Time to maximal recovery after first statin rechallenge discontinued | 62 | 10 | 27 ± 43 | 0.14–208 |
Time to complete recovery after first statin rechallenge discontinued (confined to those reporting complete recovery) | 33 | 4 | 9 ± 14 | 0.14–78 |
MAEs = muscle-related adverse effects.
0.14 wk = 1 day.
Limited to patients with time course data for both index and rechallenge MAEs.
Paired t test for index MAE onset vs first rechallenge onset, p=0.0014.
Paired t test for index MAE recovery vs first rechallenge recovery, p=0.24.