Abstract
A case of primary macroglobulinaemia of Waldenström is described in which prolonged treatment with the alkylating agents of cyclophosphamide and chlorambucil led to a sustained reduction in the concentration of circulating macroglobulin together with a concurrent improvement in the patient's symptoms.
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- BAYRD E. D. Continuous chlorambucil therapy in primary macroglobulinemia of Waldenstrom: report of four cases. Proc Staff Meet Mayo Clin. 1961 Mar 15;36:135–147. [PubMed] [Google Scholar]
- CLATANOFF D. V., MEYER O. O. Response to chlorambucil in macroglobulinemia. JAMA. 1963 Jan 5;183:40–44. doi: 10.1001/jama.1963.63700010013014d. [DOI] [PubMed] [Google Scholar]
- CONWAY N., WALKER J. M. Treatment of macroglobulinaemia. Br Med J. 1962 Nov 17;2(5315):1296–1297. doi: 10.1136/bmj.2.5315.1296. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DEUTSCH H. F., MORTON J. I. Human serum macroglobulins and dissociation units. I. Physicochemical properties. J Biol Chem. 1958 Apr;231(2):1107–1118. [PubMed] [Google Scholar]
- FAIRLEY G. H. THE TREATMENT OF MALIGNANT DISEASES ASSOCIATED WITH GAMMA GLOBULIN ABNORMALITIES. Proc R Soc Med. 1963 Aug;56:637–639. doi: 10.1177/003591576305600803. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GLENCHUR H., ZINNEMAN H. H., BRIGGS D. R. Macroglobulinemia: report of two cases. Ann Intern Med. 1958 May;48(5):1055–1069. doi: 10.7326/0003-4819-48-5-1055. [DOI] [PubMed] [Google Scholar]
- KAPPELER R., KREBS A., RIVA G. Klinik der Makroglobulinämie Waldenström; Beschreibung von 21 Fallen und Ubersicht der Literatur. Helv Med Acta. 1958 Apr;25(1):54–contd. [PubMed] [Google Scholar]
- KOK D. A., WHITMORE D. N., AINSWORTH R. W. FOUR CASES OF WALDENSTROEM'S MACROGLOBULINAEMIA. J Clin Pathol. 1963 Jul;16:351–361. doi: 10.1136/jcp.16.4.351. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LOGOTHETIS J., SILVERSTEIN P., COE J. Neurologic aspects of Waldenstrom's macroglobulinemia; report of a case. Arch Neurol. 1960 Nov;3:564–573. doi: 10.1001/archneur.1960.00450050084010. [DOI] [PubMed] [Google Scholar]
- MACKAY I. R., ERIKSEN N., MOTULSKY A. G., VOLWILER W. Cryo- and macroglobulinemia; electrophoretic, ultracentrifugal and clinical studies. Am J Med. 1956 Apr;20(4):564–587. doi: 10.1016/0002-9343(56)90139-5. [DOI] [PubMed] [Google Scholar]
- MACKAY I. R. Macroglobulins and macroglobulinaemia. Australas Ann Med. 1959 May;8(2):158–170. doi: 10.1111/imj.1959.8.2.158. [DOI] [PubMed] [Google Scholar]
- MARTIN N. H. Macroglobulinaemia. A clinical and pathological study. Q J Med. 1960 Apr;29:179–197. [PubMed] [Google Scholar]
- PITNEY W. R., O'SULLIVAN W. J., OWEN J. A. Effect of prednisolone on anaemia associated with macroglobulinemia. Br Med J. 1958 Dec 20;2(5111):1508–1510. doi: 10.1136/bmj.2.5111.1508. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RITZMANN S. E., COLEMAN S. L., LEVIN W. C. The effect of some mercaptanes upon a macrocryogelglobulin; modifications induced by cysteamine, penicillamine and penicillin. J Clin Invest. 1960 Aug;39:1320–1329. doi: 10.1172/JCI104149. [DOI] [PMC free article] [PubMed] [Google Scholar]
- RITZMANN S. E., THURM R. H., TRUAX W. E., LEVIN W. C. The syndrome of macroglobulinemia. Review of the literature and a report of two cases of macrocryogelglobulinemia. Arch Intern Med. 1960 Jun;105:939–965. [PubMed] [Google Scholar]
- SCHWAB P. J., FAHEY J. L. Treatment of Waldenstrom's macroglobulinemia by plasmapheresis. N Engl J Med. 1960 Sep 22;263:574–579. doi: 10.1056/NEJM196009222631202. [DOI] [PubMed] [Google Scholar]
- SKOOG W. A., ADAMS W. S., COBURN J. W. Metabolic balance study of plasmapheresis in a case of Waldenstrom's macroglobulinemia. Blood. 1962 Apr;19:425–438. [PubMed] [Google Scholar]
- SPALTER H. F. Abnormal serum proteins and retinal vein thrombosis. Arch Ophthalmol. 1959 Nov;62:868–881. doi: 10.1001/archopht.1959.04220050128021. [DOI] [PubMed] [Google Scholar]
- ZOLLINGER H. U. Die pathologische Anatomie der Makroglobulinämie Waldenström. Helv Med Acta. 1958 May;25(2):153–183. [PubMed] [Google Scholar]

