Abstract
The incidence of lymphopenia and eosinopenia in 10 patients admitted to hospital in heart failure was compared with that in 11 `cold' admissions and 10 with acute diseases admitted via the Casualty Department. Plasma cortisol determinations were made simultaneously. A significant difference was found between the heart failure group and the `cold' controls in respect of lymphopenia, eosinopenia, and cortisol levels. The `acute' control patients showed an overlap with both groups. It is concluded that this lymphopenia is part of a response to stress.
Seventy-two hours after admission there was no significant change in these values although the figures suggest the beginning of a return to normal.
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- BLISS E. L., NELSON D. H., SAMUELS L. T. Effects of intravenous ACTH on blood levels of 17-hydroxycorticosteroids and circulating leukocytes. J Clin Endocrinol Metab. 1954 Apr;14(4):423–439. doi: 10.1210/jcem-14-4-423. [DOI] [PubMed] [Google Scholar]
- FRANK J. A., DOUGHERTY T. F. The assessment of stress in human subjects by means of quantitative and qualitative changes of blood lymphocytes. J Lab Clin Med. 1953 Oct;42(4):538–549. [PubMed] [Google Scholar]
- GOLDMAN R., BASSETT S. H. Diurnal variation in the urinary excretion of neutral lipid-soluble reducing steroids in congestive cardiac failure and cirrhosis of the liver with ascites. J Clin Invest. 1952 Mar;31(3):253–258. doi: 10.1172/JCI102600. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. doi: 10.1136/jcp.15.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MOORE F. D. Endocrine changes after anesthesia, surgery, and unanesthetized trauma in man. Recent Prog Horm Res. 1957;13:511–582. [PubMed] [Google Scholar]
- PERKOFF G. T., EIK-NES K., NUGENT C. A., FRED H. L., NIMER R. A., RUSH L., SAMUELS L. T., TYLER F. H. Studies of the diurnal variation of plasma 17-hydroxycorticosteroids in man. J Clin Endocrinol Metab. 1959 Apr;19(4):432–443. doi: 10.1210/jcem-19-4-432. [DOI] [PubMed] [Google Scholar]
- SKEGGS L. T., Jr An automatic method for colorimetric analysis. Am J Clin Pathol. 1957 Sep;28(3):311–322. doi: 10.1093/ajcp/28.3_ts.311. [DOI] [PubMed] [Google Scholar]
- Shillitoe A. J. The Common Causes of Lymphopenia. J Clin Pathol. 1950 Nov;3(4):321–331. doi: 10.1136/jcp.3.4.321. [DOI] [PMC free article] [PubMed] [Google Scholar]