Abstract
During the past 10 years there has been particular interest in the occurrence of a number of endocrine syndromes in association with tumours of organs other than the endocrines. Evidence is increasing to suggest that these result from the formation of hormone-like substances by the tumours. The clinical importance and theoretical implications of these syndromes constitute the justification for reviewing them here.
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- ALLOTT E. N., SKELTON M. O. Increased adrenocortical activity associated with malignant disease. Lancet. 1960 Aug 6;2(7145):278–284. doi: 10.1016/s0140-6736(60)91374-x. [DOI] [PubMed] [Google Scholar]
- AMATRUDA T. T., Jr, MULROW P. J., GALLAGHER J. C., SAWYER W. H. CARCINOMA OF THE LUNG WITH INAPPROPRIATE ANTIDIURESIS. DEMONSTRATION OF ANTIDIURETIC-HORMONE-LIKE ACTIVITY IN TUMOR EXTRACT. N Engl J Med. 1963 Sep 12;269:544–549. doi: 10.1056/NEJM196309122691102. [DOI] [PubMed] [Google Scholar]
- AUGUST J. T., HIATT H. H. Severe hypoglycemia secondary to a nonpancreatic fibrosarcoma with insulin activity. N Engl J Med. 1958 Jan 2;258(1):17–20. doi: 10.1056/NEJM195801022580104. [DOI] [PubMed] [Google Scholar]
- BATES R. W., CORNFIELD J. An improved assay method for thyrotrophin using depletion of I 131 from the thyroid of day-old chicks. Endocrinology. 1957 Feb;60(2):225–238. doi: 10.1210/endo-60-2-225. [DOI] [PubMed] [Google Scholar]
- DALY J. J., NELSON M. A., ROSE D. P. Hyponatremia with carcinoma of the bronchus. Postgrad Med J. 1963 Mar;39:158–159. doi: 10.1136/pgmj.39.449.158. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Doege K. W. FIBRO-SARCOMA OF THE MEDIASTINUM. Ann Surg. 1930 Nov;92(5):955–960. [PMC free article] [PubMed] [Google Scholar]
- ERICSON A. T., CLEGG R. E., HEIN R. E. Influence of calcium on mobility of the electrophoretic components of chicken blood serums. Science. 1955 Jul 29;122(3161):199–200. doi: 10.1126/science.122.3161.199. [DOI] [PubMed] [Google Scholar]
- GELLHORN A., PLIMPTON C. H. Hypercalcemia in malignant disease without evidence of bone destruction. Am J Med. 1956 Nov;21(5):750–759. [PubMed] [Google Scholar]
- GHOSE T., NAIRN R. C., FOTHERGILL J. E. Uptake of proteins by malignant cells. Nature. 1962 Dec 15;196:1108–1109. doi: 10.1038/1961108b0. [DOI] [PubMed] [Google Scholar]
- GINSBURG J., BROWN J. B. Increased oestrogen excretion in hypertrophic pulmonary osteoarthropathy. Lancet. 1961 Dec 9;2(7215):1274–1276. doi: 10.1016/s0140-6736(61)91139-4. [DOI] [PubMed] [Google Scholar]
- GOLDBERG M. F., TASHJIAN A. H., Jr, ORDER S. E., DAMMIN G. J. RENAL ADENOCARCINOMA CONTAINING A PARATHYROID HORMONE-LIKE SUBSTANCE AND ASSOCIATED WITH MARKED HYPERCALCEMIA. Am J Med. 1964 May;36:805–814. doi: 10.1016/0002-9343(64)90188-3. [DOI] [PubMed] [Google Scholar]
- GOWENLOCK A. H., PLATT D. S., CAMPBELL A. C., WORMSLEY K. G. OAT-CELL CARCINOMA OF THE BRONCHUS SECRETING 5-HYDROXYTRYPTOPHAN. Lancet. 1964 Feb 8;1(7328):304–306. doi: 10.1016/s0140-6736(64)92411-0. [DOI] [PubMed] [Google Scholar]
- GREENBERG E., DIVERTIE M. B., WOOLNER L. B. A REVIEW OF UNUSUAL SYSTEMIC MANIFESTATIONS ASSOCIATED WITH CARCINOMA. Am J Med. 1964 Jan;36:106–120. doi: 10.1016/0002-9343(64)90153-6. [DOI] [PubMed] [Google Scholar]
- GREGORY R. A., TRACY H. J., FRENCH J. M., SIRCUS W. Extraction of a gastrin-like substance from a pancreatic tumour in a case of Zollinger-Ellison syndrome. Lancet. 1960 May 14;1(7133):1045–1048. doi: 10.1016/s0140-6736(60)90932-6. [DOI] [PubMed] [Google Scholar]
- HARDY J. D. Gynecomastia associated with lung cancer. JAMA. 1960 Jul 30;173:1462–1465. doi: 10.1001/jama.1960.03020310050015. [DOI] [PubMed] [Google Scholar]
- HUNG W., BLIZZARD R. M., MIGEON C. J., CAMACHO A. M., NYHAN W. L. PRECOCIOUS PUBERTY IN A BOY WITH HEPATOMA AND CIRCULATING GONADOTROPIN. J Pediatr. 1963 Nov;63:895–903. doi: 10.1016/s0022-3476(63)80220-6. [DOI] [PubMed] [Google Scholar]
- HYMES A. C., DOE R. P. Adrenal function in cancer of the lung, with and without Cushing's syndrome. Am J Med. 1962 Sep;33:398–407. doi: 10.1016/0002-9343(62)90236-x. [DOI] [PubMed] [Google Scholar]
- LEE J., JONES J. J., BARRACLOUGH M. A. INAPPROPRIATE SECRETION OF VASOPRESSIN. Lancet. 1964 Oct 10;2(7363):792–793. doi: 10.1016/s0140-6736(64)90566-5. [DOI] [PubMed] [Google Scholar]
- LIDDLE G. W., ISLAND D. P., NEY R. L., NICHOLSON W. E., SHIMIZU N. Nonpituitary neoplasms and Cushing's syndrome. Ectopic "adrenocorticotropin" produced by nonpituitary neoplasms as a cause of Cushing's syndrome. Arch Intern Med. 1963 Apr;111:471–475. doi: 10.1001/archinte.1963.03620280071011. [DOI] [PubMed] [Google Scholar]
- LIPSETT M. B., ODELL W. D., ROSENBERG L. E., WALDMANN T. A. HUMORAL SYNDROMES ASSOCIATED WITH NONENDOCRINE TUMORS. Ann Intern Med. 1964 Oct;61:733–756. doi: 10.7326/0003-4819-61-4-733. [DOI] [PubMed] [Google Scholar]
- LOWBEER L. Hypoglycemia-producing extrapancreatic neoplasms. A review. Am J Clin Pathol. 1961 Mar;35:233–243. doi: 10.1093/ajcp/35.3.233. [DOI] [PubMed] [Google Scholar]
- LUCAS P. F. Acute hypercalcaemia from carcinomatosis without bone metastasis. Br Med J. 1960 Apr 30;1(5182):1330–1331. doi: 10.1136/bmj.1.5182.1330. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MASSARO D. J., OWEN J. A., Jr Persistent hypercalcemia associated with bronchogenic carcinoma and primary chiefcell hyperplasia of the parathyroids. Am Rev Respir Dis. 1962 May;85:727–734. doi: 10.1164/arrd.1962.85.5.727. [DOI] [PubMed] [Google Scholar]
- MEADOR C. K., LIDDLE G. W., ISLAND D. P., NICHOLSON W. E., LUCAS C. P., NUCKTON J. G., LUETSCHER J. A. Cause of Cushing's syndrome in patients with tumors arising from "nonendocrine" tissue. J Clin Endocrinol Metab. 1962 Jul;22:693–703. doi: 10.1210/jcem-22-7-693. [DOI] [PubMed] [Google Scholar]
- MILLER D. R., BOLINGER R. E., JANIGAN D., CROCKETT J. E., FRIESEN S. R. Hypoglycemia due to nonpancreatic mesodermal tumors: report of two cases. Ann Surg. 1959 Oct;150:684–696. doi: 10.1097/00000658-195910000-00012. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MONACO A. P., LYTHGOE J. P., WADDELL W. R. Immunological study in the Zollinger-Ellison syndrome. Lancet. 1961 Nov 4;2(7210):1016–1017. doi: 10.1016/s0140-6736(61)90971-0. [DOI] [PubMed] [Google Scholar]
- ODELL W. D., BATES R. W., RIVLIN R. S., LIPSETT M. B., HERTZ R. Increased thyroid function without clinical hyperthyroidism in patients with choriocarcinoma. J Clin Endocrinol Metab. 1963 Jul;23:658–664. doi: 10.1210/jcem-23-7-658. [DOI] [PubMed] [Google Scholar]
- OLEESKY S., BAILEY I., SAMOLS E., BILKUS D. A fibrosarcoma with hypoglycaemia and a high serum-insulin level. Lancet. 1962 Aug 25;2(7252):378–380. doi: 10.1016/s0140-6736(62)90231-3. [DOI] [PubMed] [Google Scholar]
- PEART W. S., PORTER K. A., ROBERTSON J. I., SANDLER M., BALDOCK E. Carcinoid syndrome due to pancreatic-duct neoplasm secreting 5-hydroxytryptophan and 5-hydroxytryptamine. Lancet. 1963 Feb 2;1(7275):239–243. doi: 10.1016/s0140-6736(63)90952-8. [DOI] [PubMed] [Google Scholar]
- PRIEST W. M., ALEXANDER M. K. Isletcell tumour of the pancreas with peptic ulceration, diarrhoea, and hypokalaemia. Lancet. 1957 Dec 7;273(7006):1145–1147. doi: 10.1016/s0140-6736(57)92051-2. [DOI] [PubMed] [Google Scholar]
- PRUNTY F. T., BROOKS R. V., DUPRE J., GIMLETTE T. M., HUTCHINSON J. S., MCSWINEY R. R., MILLS I. H. ADRENOCORTICAL HYPERFUNCTION AND POTASSIUM METABOLISM IN PATIENTS WITH "NON- ENDOCRINE" TUMORS AND CUSHING'S SYNDROME. J Clin Endocrinol Metab. 1963 Aug;23:737–746. doi: 10.1210/jcem-23-8-737. [DOI] [PubMed] [Google Scholar]
- Penington D. G. Endocrine Dysfunction in Malignant Disease. Proc R Soc Med. 1965 Jul;58(7):488–490. [PMC free article] [PubMed] [Google Scholar]
- REES J. R., ROSALKI S. B., MACLEAN A. D. Hyponatraemia and impaired renal tubular function with carcinoma of bronchus. Lancet. 1960 Nov 5;2(7158):1005–1009. doi: 10.1016/s0140-6736(60)92081-x. [DOI] [PubMed] [Google Scholar]
- REEVES R. L., TESLUK H., HARRISON C. E. Precocious puberty associated with hepatoma. J Clin Endocrinol Metab. 1959 Dec;19:1651–1660. doi: 10.1210/jcem-19-12-1651. [DOI] [PubMed] [Google Scholar]
- RIGGS B. L., Jr, SPRAGUE R. G. Association of Cushing's syndrome and neoplastic disease: observations in 232 cases of Cushing's syndrome and review of the literature. Arch Intern Med. 1961 Dec;108:841–849. doi: 10.1001/archinte.1961.03620120025005. [DOI] [PubMed] [Google Scholar]
- ROSS E. J. HYPONATRAEMIC SYNDROMES ASSOCIATED WITH CARCINOMA OF THE BRONCHUS. Q J Med. 1963 Oct;32:297–320. [PubMed] [Google Scholar]
- SCHATTEN W. E., SHIP A. G., PIEPER W. J., BARTTER F. C. Syndrome resembling hyperparathyroidism associated with squamous cell carcinoma. Ann Surg. 1958 Dec;148(6):890–894. doi: 10.1097/00000658-195812000-00004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SCHONFELD A., BABBOTT D., GUNDERSEN K. Hypoglycemia and polycythemia associated with primary hepatoma. N Engl J Med. 1961 Aug 3;265:231–233. doi: 10.1056/NEJM196108032650506. [DOI] [PubMed] [Google Scholar]
- SCHWARTZ W. B., BENNETT W., CURELOP S., BARTTER F. C. A syndrome of renal sodium loss and hyponatremia probably resulting from inappropriate secretion of antidiuretic hormone. Am J Med. 1957 Oct;23(4):529–542. doi: 10.1016/0002-9343(57)90224-3. [DOI] [PubMed] [Google Scholar]
- SOUTTER L., SOMMERS S., RELMAN A. S., EMERSON C. P. Problems in the surgical management of thymic tumors. Ann Surg. 1957 Sep;146(3):424–438. doi: 10.1097/00000658-195709000-00011. [DOI] [PMC free article] [PubMed] [Google Scholar]
- STEIGBIGEL N. H., OPPENHEIM J. J., FISHMAN L. M., CARBONE P. P. METASTATIC EMBRYONAL CARCINOMA OF THE TESTIS ASSOCIATED WITH ELEVATED PLASMA TSH-LIKE ACTIVITY AND HYPERTHYROIDISM. N Engl J Med. 1964 Aug 13;271:345–349. doi: 10.1056/NEJM196408132710704. [DOI] [PubMed] [Google Scholar]
- Samaan N., Lal F., Fraser R., Welbourn R. B. Insulin Assays in Two Cases of Spontaneous Hypoglycaemia Due to Retroperitoneal Mesothelioma. Br Med J. 1965 Jul 24;2(5455):195–198. doi: 10.1136/bmj.2.5455.195. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TASHJIAN A. H., Jr, LEVINE L., MUNSON P. L. IMMUNOASSAY OF PARATHYROID HORMONE BY QUANTITATIVE COMPLEMENT FIXATION. Endocrinology. 1964 Feb;74:244–254. doi: 10.1210/endo-74-2-244. [DOI] [PubMed] [Google Scholar]
- TRANQUADA R. E., BENDER A. B., BEIGELMAN P. M. Hypoglycemia associated with carcinoma of the cecum and syndrome of testicular feminization. N Engl J Med. 1962 Jun 21;266:1302–1306. doi: 10.1056/NEJM196206212662503. [DOI] [PubMed] [Google Scholar]
- UNGER R. H., LOCHNERJDE V., EISENTRAUT A. M. IDENTIFICATION OF INSULIN AND GLUGACON IN A BRONCHOGENIC METASTASIS. J Clin Endocrinol Metab. 1964 Sep;24:823–831. doi: 10.1210/jcem-24-9-823. [DOI] [PubMed] [Google Scholar]
- VAN DER VEER J. S., CHOUFOER J. C., QUERIDO A., VAN DER HEUL R. O., HOLLANDER C. F., VAN RIJSSEL T. METASTASISING ISLET-CELL TUMOUR OF THE PANCREAS ASSOCIATED WITH HYPOGLYCAEMIA AND CARCINOID SYNDROME. Lancet. 1964 Jun 27;2(7348):1416–1419. doi: 10.1016/s0140-6736(64)91985-3. [DOI] [PubMed] [Google Scholar]
- WALSER M. The separate effects of hyperparathyroidism, hypercalcemia of malignancy, renal failure, and acidosis on the state of calcium, phosphate, and other ions in plasma. J Clin Invest. 1962 Jul;41:1454–1471. doi: 10.1172/JCI104601. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WATSON L. HYPERCALCAEMIA AND CANCER. Postgrad Med J. 1963 Nov;39:646–649. doi: 10.1136/pgmj.39.457.646. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WERK E. E., Jr, SHOLITON L. J. Adrenocortical function in carcinoma of the lung. Cancer. 1960 May-Jun;13:469–481. doi: 10.1002/1097-0142(196005/06)13:3<469::aid-cncr2820130309>3.0.co;2-k. [DOI] [PubMed] [Google Scholar]
- WHITNEY J. E., MASSEY C. G. Apparent insulin activity in a fibrosarcoma associated with spontaneous hypoglycemia. J Clin Endocrinol Metab. 1961 May;21:541–547. doi: 10.1210/jcem-21-5-541. [DOI] [PubMed] [Google Scholar]
- WILLIAMS E. D., AZZOPARDI J. G. Tumours of the lung and the carcinoid syndrome. Thorax. 1960 Mar;15:30–36. doi: 10.1136/thx.15.1.30. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WILLIAMS E. D., SANDLER M. The classification of carcinoid tum ours. Lancet. 1963 Feb 2;1(7275):238–239. doi: 10.1016/s0140-6736(63)90951-6. [DOI] [PubMed] [Google Scholar]
- WILLIAMS W. C., Jr, ISLAND D., OLDFIELD R. A., Jr, LIDDLE G. W. Blood corticotropin (ACTH) levels in Cushing's disease. J Clin Endocrinol Metab. 1961 Apr;21:426–432. doi: 10.1210/jcem-21-4-426. [DOI] [PubMed] [Google Scholar]
- ZOLLINGER R. M., ELLISON E. H. Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas. Ann Surg. 1955 Oct;142(4):709-23; discussion, 724-8. [PMC free article] [PubMed] [Google Scholar]
- de GENNES, BRICAIRE H., LEPRAT J. [Paraneoplastic endocrine syndromes. II. Hyperthyroidism and various endocrinopathies]. Presse Med. 1962 Oct 27;70:2137–2139. [PubMed] [Google Scholar]