Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1966 Mar;19(2):128–132. doi: 10.1136/jcp.19.2.128

Assessment of the combined usefulness in thyroid function testing of the triiodothyronine resin-sponge and 24-hour iodine uptakes

R A Carter 1
PMCID: PMC473203  PMID: 4160094

Abstract

Iodine and resin sponge uptake tests have been performed upon 124 consecutive patients referred for thyroid studies. Neither test alone could correctly identify all cases of thyrotoxicosis or myxoedema, but when considered in combination diagnostic efficiency was much improved. This combination of tests is shown to be especially useful in the investigation of patients with changes in body iodine pools or thyroxine-binding globulin levels.

Reasons are given for regarding this pair of tests as being more generally useful than any of the other possible combinations at present available. The resin sponge test kit was found to be satisfactory both technically and in respect of cost.

Full text

PDF
128

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. FREEDBERG A. S., HAMOLSKY M. W., STEIN M. The thyroid hormone-plasma protein complex in man. II. A new in vitro method for study of uptake of labelled hormonal components by human erythrocytes. J Clin Endocrinol Metab. 1957 Jan;17(1):33–43. doi: 10.1210/jcem-17-1-33. [DOI] [PubMed] [Google Scholar]
  2. FRIIS T. In vitro uptake of 131-I labelled 1-triiodothyronine by human erythrocytes. Acta Endocrinol (Copenh) 1960 Jan;33:117–133. doi: 10.1530/acta.0.xxxiii0117. [DOI] [PubMed] [Google Scholar]
  3. GIMLETTE T. M. A SIMPLE TECHNIQUE USING 'DIALYSABLE' THYROXINE FOR ASSESSMENT OF THYROID STATUS. J Clin Pathol. 1964 Jan;17:58–60. doi: 10.1136/jcp.17.1.58. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. HAMOLSKY M. W., GOLODETZ A., FREEDBERG A. S. The plasma protein-thyroid hormone complex in man. III. Further studies on the use of the in vitro red blood cell up take of I 131-1-triiodothyronine as a diagnostic test of thyroid function. J Clin Endocrinol Metab. 1959 Jan;19(1):103–116. doi: 10.1210/jcem-19-1-103. [DOI] [PubMed] [Google Scholar]
  5. MITCHELL M. L., HARDEN A. B., O'ROURKE M. E. The in vitro resin sponge uptake of triiodothyronine-I-131 from serum in thyroid disease and in pregnancy. J Clin Endocrinol Metab. 1960 Nov;20:1474–1483. doi: 10.1210/jcem-20-11-1474. [DOI] [PubMed] [Google Scholar]
  6. NAVA M., DE GROOT L. J. Resin uptake of I-131-labeled triiodothyronine as a test of thyroid function. N Engl J Med. 1962 Jun 21;266:1307–1310. doi: 10.1056/NEJM196206212662504. [DOI] [PubMed] [Google Scholar]
  7. OPPENHEIMER J. H., FISHER L. V., NELSON K. M., JAILER J. W. Depression of the serum protein-bound iodine level by diphenylhydantion. J Clin Endocrinol Metab. 1961 Mar;21:252–262. doi: 10.1210/jcem-21-3-252. [DOI] [PubMed] [Google Scholar]
  8. QUIMBY E. H., HIZA E. EVALUATION OF THE RESIN UPTAKE OF I-131 TRIIODOTHYRONINE AS A TEST OF THYROID FUNCTION. J Nucl Med. 1964 Jul;5:489–499. [PubMed] [Google Scholar]
  9. ROBBINS L. R. Experience with the in vitro erythrocyte uptake of I 13 I-labeled 1-triiodothyronine in a routine clinical laboratory. J Clin Endocrinol Metab. 1959 Oct;19:1292–1301. doi: 10.1210/jcem-19-10-1292. [DOI] [PubMed] [Google Scholar]
  10. TAUXE W. N., YAMAGUCHI M. Y. Variants affecting results of red cell triiodothyronine uptake test. Am J Clin Pathol. 1961 Jul;36:1–6. doi: 10.1093/ajcp/36.1.1. [DOI] [PubMed] [Google Scholar]
  11. URELES A. L., MURRAY M. The erythrocyte uptake of I 131-labeled 1-triiodothyronine as a measure of thyroid function. J Lab Clin Med. 1959 Aug;54:178–185. [PubMed] [Google Scholar]
  12. WAGNER H. N., Jr, NELP W. B., WATTS J. C. Clinical and experimental evaluation of the triiodothyronine (T3) red cell uptake test. Bull Johns Hopkins Hosp. 1961 Mar;108:161–170. [PubMed] [Google Scholar]
  13. WALFISH P. G., BRITTON A., VOLPE R., EZRIN C. Experience with an in vitro test of thyroid function--the red blood cell uptake of L-triiodothyronine labelled with radioactive iodine. Can Med Assoc J. 1961 Mar 25;84:637–641. [PMC free article] [PubMed] [Google Scholar]
  14. YOUNG R. W., NICHOLAS W. C., MACGREGOR P. A., RUSTED I. The in vitro radioactive triiodothyronine uptake of erythrocytes as a test of thyroid function. Can Med Assoc J. 1960 Nov 26;83:1160–1162. [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES