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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1993 Sep 1;90(17):8239–8243. doi: 10.1073/pnas.90.17.8239

Abundant mitochondrial DNA variation and world-wide population structure in humpback whales.

C S Baker 1, A Perry 1, J L Bannister 1, M T Weinrich 1, R B Abernethy 1, J Calambokidis 1, J Lien 1, R H Lambertsen 1, J U Ramírez 1, O Vasquez 1, et al.
PMCID: PMC47324  PMID: 8367488

Abstract

Hunting during the last 200 years reduced many populations of mysticete whales to near extinction. To evaluate potential genetic bottlenecks in these exploited populations, we examined mitochondrial DNA control region sequences from 90 individual humpback whales (Megaptera novaeangliae) representing six subpopulations in three ocean basins. Comparisons of relative nucleotide and nucleotype diversity reveal an abundance of genetic variation in all but one of the oceanic subpopulations. Phylogenetic reconstruction of nucleotypes and analysis of maternal gene flow show that current genetic variation is not due to postexploitation migration between oceans but is a relic of past population variability. Calibration of the rate of control region evolution across three families of whales suggests that existing humpback whale lineages are of ancient origin. Preservation of preexploitation variation in humpback whales may be attributed to their long life-span and overlapping generations and to an effective, though perhaps not timely, international prohibition against hunting.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Arnason U., Grétarsdóttir S., Widegren B. Mysticete (baleen whale) relationships based upon the sequence of the common cetacean DNA satellite. Mol Biol Evol. 1992 Nov;9(6):1018–1028. doi: 10.1093/oxfordjournals.molbev.a040776. [DOI] [PubMed] [Google Scholar]
  2. Arnason U., Gullberg A., Widegren B. The complete nucleotide sequence of the mitochondrial DNA of the fin whale, Balaenoptera physalus. J Mol Evol. 1991 Dec;33(6):556–568. doi: 10.1007/BF02102808. [DOI] [PubMed] [Google Scholar]
  3. Baker C. S., Palumbi S. R., Lambertsen R. H., Weinrich M. T., Calambokidis J., O'Brien S. J. Influence of seasonal migration on geographic distribution of mitochondrial DNA haplotypes in humpback whales. Nature. 1990 Mar 15;344(6263):238–240. doi: 10.1038/344238a0. [DOI] [PubMed] [Google Scholar]
  4. Cann R. L., Stoneking M., Wilson A. C. Mitochondrial DNA and human evolution. Nature. 1987 Jan 1;325(6099):31–36. doi: 10.1038/325031a0. [DOI] [PubMed] [Google Scholar]
  5. Excoffier L., Smouse P. E., Quattro J. M. Analysis of molecular variance inferred from metric distances among DNA haplotypes: application to human mitochondrial DNA restriction data. Genetics. 1992 Jun;131(2):479–491. doi: 10.1093/genetics/131.2.479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Felsenstein J. Evolutionary trees from DNA sequences: a maximum likelihood approach. J Mol Evol. 1981;17(6):368–376. doi: 10.1007/BF01734359. [DOI] [PubMed] [Google Scholar]
  7. Hoelzel A. R., Hancock J. M., Dover G. A. Evolution of the cetacean mitochondrial D-loop region. Mol Biol Evol. 1991 Jul;8(4):475–493. doi: 10.1093/oxfordjournals.molbev.a040662. [DOI] [PubMed] [Google Scholar]
  8. Hultman T., Ståhl S., Hornes E., Uhlén M. Direct solid phase sequencing of genomic and plasmid DNA using magnetic beads as solid support. Nucleic Acids Res. 1989 Jul 11;17(13):4937–4946. doi: 10.1093/nar/17.13.4937. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Li W. H., Wu C. I., Luo C. C. A new method for estimating synonymous and nonsynonymous rates of nucleotide substitution considering the relative likelihood of nucleotide and codon changes. Mol Biol Evol. 1985 Mar;2(2):150–174. doi: 10.1093/oxfordjournals.molbev.a040343. [DOI] [PubMed] [Google Scholar]
  10. Saiki R. K., Gelfand D. H., Stoffel S., Scharf S. J., Higuchi R., Horn G. T., Mullis K. B., Erlich H. A. Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science. 1988 Jan 29;239(4839):487–491. doi: 10.1126/science.2448875. [DOI] [PubMed] [Google Scholar]
  11. Saitou N., Nei M. The neighbor-joining method: a new method for reconstructing phylogenetic trees. Mol Biol Evol. 1987 Jul;4(4):406–425. doi: 10.1093/oxfordjournals.molbev.a040454. [DOI] [PubMed] [Google Scholar]
  12. Slatkin M., Maddison W. P. Detecting isolation by distance using phylogenies of genes. Genetics. 1990 Sep;126(1):249–260. doi: 10.1093/genetics/126.1.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Vigilant L., Stoneking M., Harpending H., Hawkes K., Wilson A. C. African populations and the evolution of human mitochondrial DNA. Science. 1991 Sep 27;253(5027):1503–1507. doi: 10.1126/science.1840702. [DOI] [PubMed] [Google Scholar]

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