Abstract
The insulin test carried out with adequate safeguards under standardized conditions yields valuable information regarding hypothalamic and pituitary function when plasma levels of sugar, cortisol, and growth hormone are determined. The use of a test based on the plasma cortisol response to the infusion of lysine-vasopressin, a polypeptide with a corticotrophin-releasing action, is also of value as a test of pituitary function. Used in conjunction with the insulin test it enables pituitary disorders to be differentiated from those involving the hypothalamus.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- CLAYTON G. W., LIBRIK L., GARDNER R. L., GUILLEMIN R. STUDIES ON THE CIRCADIAN RHYTHM OF PITUITARY ADRENOCORTICOTROPIC RELEASE IN MAN. J Clin Endocrinol Metab. 1963 Oct;23:975–980. doi: 10.1210/jcem-23-10-975. [DOI] [PubMed] [Google Scholar]
- FRANTZ A. G., RABKIN M. T. HUMAN GROWTH HORMONE. CLINICAL MEASUREMENT, RESPONSE TO HYPOGLYCEMIA AND SUPPRESSION BY CORTICOSTEROIDS. N Engl J Med. 1964 Dec 31;271:1375–1381. doi: 10.1056/NEJM196412312712701. [DOI] [PubMed] [Google Scholar]
- GLICK S. M., ROTH J., YALOW R. S., BERSON S. A. IMMUNOASSAY OF HUMAN GROWTH HORMONE IN PLASMA. Nature. 1963 Aug 24;199:784–787. doi: 10.1038/199784a0. [DOI] [PubMed] [Google Scholar]
- GREENWOOD F. C., HUNTER W. M., MARRIAN V. J. GROWTH-HORMONE LEVELS IN CHILDREN AND ADOLESCENTS. Br Med J. 1964 Jan 4;1(5374):25–26. doi: 10.1136/bmj.1.5374.25. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Greenwood F. C., Stewart H. J., Forrest A. P., Wood R. G. Plasma-growth-hormone levels in untreated acromegaly and after radioactive implants into the pituitary. Lancet. 1965 Sep 18;2(7412):555–558. doi: 10.1016/s0140-6736(65)90865-2. [DOI] [PubMed] [Google Scholar]
- Gwinup G. Test for pituitary function using vasopressin. Lancet. 1965 Sep 18;2(7412):572–573. doi: 10.1016/s0140-6736(65)90873-1. [DOI] [PubMed] [Google Scholar]
- HARRIS G. W. Neural control of the pituitary gland. II. The adenohypophysis, with special reference to the secretion of A.C.T.H. Br Med J. 1951 Sep 15;2(4732):627–634. doi: 10.1136/bmj.2.4732.627. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HARTOG M., GAAFAR M. A., FRASER R. EFFECT OF CORTICOSTEROIDS ON SERUM GROWTH HORMONE. Lancet. 1964 Aug 22;2(7356):376–378. doi: 10.1016/s0140-6736(64)90389-7. [DOI] [PubMed] [Google Scholar]
- Hunter W. M., Greenwood F. C. A radio-immunoelectrophoretic assay for human growth hormone. Biochem J. 1964 Apr;91(1):43–56. doi: 10.1042/bj0910043. [DOI] [PMC free article] [PubMed] [Google Scholar]
- KNOPF R. F., CONN J. W., FAJANS S. S., FLOYD J. C., GUNTSCHE E. M., RULL J. A. PLASMA GROWTH HORMONE RESPONSE TO INTRAVENOUS ADMINISTRATION OF AMINO ACIDS. J Clin Endocrinol Metab. 1965 Aug;25:1140–1144. doi: 10.1210/jcem-25-8-1140. [DOI] [PubMed] [Google Scholar]
- LANDON J., WYNN V., JAMES V. H., WOOD J. B. ADRENAL RESPONSE TO INFUSED CORTICOTROPIN IN SUBJECTS RECEIVING GLUCOCORTICOIDS. J Clin Endocrinol Metab. 1965 May;25:602–611. doi: 10.1210/jcem-25-5-602. [DOI] [PubMed] [Google Scholar]
- LIDDLE G. W., ESTEP H. L., KENDALL J. W., Jr, WILLIAMS W. C., Jr, TOWNES A. W. Clinical application of a new test of pituitary reserve. J Clin Endocrinol Metab. 1959 Aug;19:875–894. doi: 10.1210/jcem-19-8-875. [DOI] [PubMed] [Google Scholar]
- Linfoot J. A., Greenwood F. C. Growth hormone in acromegaly: effect of heavy particle pituitary irradiation. J Clin Endocrinol Metab. 1965 Nov;25(11):1515–1518. doi: 10.1210/jcem-25-11-1515. [DOI] [PubMed] [Google Scholar]
- MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. doi: 10.1136/jcp.15.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MCDONALD R. K., WEISE V. K. Effect of pitressin on adrenocortical activity in man. Proc Soc Exp Biol Med. 1956 May;92(1):107–109. doi: 10.3181/00379727-92-22399. [DOI] [PubMed] [Google Scholar]
- McCANN S. M., BROBECK J. R. Evidence for a role of the supraopticohypophyseal system in regulation of adrenocorticotrophin secretion. Proc Soc Exp Biol Med. 1954 Nov;87(2):318–324. doi: 10.3181/00379727-87-21368. [DOI] [PubMed] [Google Scholar]
- RABEN M. S., HOLLENBERG C. H. Effect of growth hormone on plasma fatty acids. J Clin Invest. 1959 Mar;38(3):484–488. doi: 10.1172/JCI103824. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROSS E. J. The endocrinology of pituitary tumours. Proc R Soc Med. 1961 Jul;54:621–623. [PMC free article] [PubMed] [Google Scholar]
- ROTH J., GLICK S. M., YALOW R. S., BERSONSA Hypoglycemia: a potent stimulus to secretion of growth hormone. Science. 1963 May 31;140(3570):987–988. doi: 10.1126/science.140.3570.987. [DOI] [PubMed] [Google Scholar]
- SCHALLY A. V., SAFFRAN M., ZIMMERMANN B. A corticotrophin-releasing factor: partial purification and amino acid composition. Biochem J. 1958 Sep;70(1):97–103. doi: 10.1042/bj0700097. [DOI] [PMC free article] [PubMed] [Google Scholar]
- YALOW R. S., GLICK S. M., ROTH J., BERSON S. A. RADIOIMMUNOASSAY OF HUMAN PLASMA ACTH. J Clin Endocrinol Metab. 1964 Nov;24:1219–1225. doi: 10.1210/jcem-24-11-1219. [DOI] [PubMed] [Google Scholar]
- YATES F. E., URQUHART J. Control of plasma concentrations of adrenocortical hormones. Physiol Rev. 1962 Jul;42:359–433. doi: 10.1152/physrev.1962.42.3.359. [DOI] [PubMed] [Google Scholar]