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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1966 Jul;19(4):313–317. doi: 10.1136/jcp.19.4.313

Some observations on the penetration of antibiotics through mucus in vitro

B A Saggers 1, David Lawson 1
PMCID: PMC473272  PMID: 5951718

Abstract

A study has been made on the penetration values in vitro of antibiotics through hog gastric mucin at pH 7·4. Determinations have also been done on the binding of antibiotics to mucus and human plasma. The mucolytic agent N-acetyl cysteine has been studied in regard to its effect on antibiotics penetrating mucus and for any possible inactivation of antibiotics.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALBERT A. Avidity of terramycin and aureomycin for metallic cations. Nature. 1953 Aug 1;172(4370):201–201. doi: 10.1038/172201a0. [DOI] [PubMed] [Google Scholar]
  2. BOND J. M., BARBER M., LIGHTBOWN J. W., WATERWORTH P. M. A COMPARISON OF FOUR PHENOXYPENICILLINS. Br Med J. 1963 Oct 19;2(5363):956–961. doi: 10.1136/bmj.2.5363.956. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. CHERNICK W. S., BARBERO G. J. Composition of tracheobronchial secretions in cystic fibrosis of the pancreas and bronchiectasis. Pediatrics. 1959 Nov;24:739–745. [PubMed] [Google Scholar]
  4. LAWSON D., SAGGERS B. A. N.A.C. AND ANTIBIOTICS IN CYSTIC FIBROSIS. Br Med J. 1965 Jan 30;1(5430):317–317. doi: 10.1136/bmj.1.5430.317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Saggers B. A. Simple method for measuring the penetration of antibiotics through mucus. J Clin Pathol. 1966 Mar;19(2):201–201. doi: 10.1136/jcp.19.2.201. [DOI] [PMC free article] [PubMed] [Google Scholar]

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