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. 2015 Dec 8;157(2):482–496. doi: 10.1210/en.2015-1788

Figure 8.

Figure 8.

Lack of RL-D6 does not alter the PTH-induced increase in RANKL expression in vivo. Five-month-old female D6KO mice and their WT littermates (D6WT) were injected with 230 ng/g bw PTH or vehicle (Veh). The animals were killed, and tissues were collected 1 hour after injection. A–D, RANKL (A and C) and IL-6 (B and D) mRNA levels in lumbar vertebra 5 (L5) (A and B) and bone marrow (BM) (C and D) were measured by quantitative RT-PCR and normalized to β-actin mRNA levels (n = 4 animals/group). All RT-PCR values represent mean fold changes relative to those for the corresponding WT vehicle-injected control group. All statistical comparisons were performed using two-way ANOVA. *, P < .05 effect of injection within the same genotype; #, P < .05 effect of genotype within the same injection.