Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1966 Nov;19(6):577–582. doi: 10.1136/jcp.19.6.577

Presence of virus-like bodies in liver cells of patients with infectious hepatitis

Brenno Babudieri 1,2,3,1, Ernico Fiaschi 1,2,3, Remo Naccarato 1,2,3, Ludovico Antonio Scuro 1,2,3, J Haase 1,2,3, J Papa 1,2,3, F Tangucci 1,2,3
PMCID: PMC473385  PMID: 5928607

Abstract

Cytoplasmic `saccules', bordered by monolayer membranes, containing round, virus-like particles, with a diameter of about 200 Å, are described in liver cells of 11 patients suffering from viral hepatitis. The differences between this pattern, glycogenic clumps of granules, polysomes, and cytoplasmic autolysis processes are discussed.

Full text

PDF
577

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BEARCROFT W. G. Electron-microscope studies on the liver in infective hepatitis. J Pathol Bacteriol. 1962 Apr;83:383–388. doi: 10.1002/path.1700830207. [DOI] [PubMed] [Google Scholar]
  2. BEARCROFT W. G., PEACHEY R. D. Cytological and cytochemical studies on the liver in infective hepatitis. J Pathol Bacteriol. 1962 Apr;83:373–381. doi: 10.1002/path.1700830206. [DOI] [PubMed] [Google Scholar]
  3. BOLIN V. S., ALSEVER J. B., BARGER J. B., JARVIS T. B. Studies on serum and infectious hepatitis viruses of man. I. Preliminary report on the isolation of serum and infectious hepatitis viruses from man in tissue culture. Transfusion. 1961 Nov-Dec;1:360–366. doi: 10.1111/j.1537-2995.1961.tb00075.x. [DOI] [PubMed] [Google Scholar]
  4. BRAUNSTEINER H., FELLINGER K., PAKESCH F., NEUMAYR A. Weitere elektronenmikroskopische Beobachtungen bei Virushepatitiden. Klin Wochenschr. 1958 Apr 15;36(8):379–382. doi: 10.1007/BF01477091. [DOI] [PubMed] [Google Scholar]
  5. CHANG R. S. Properties of a transmissible agent capable of inducing marked DNA degradation and thymine catabolism in human cell. Proc Soc Exp Biol Med. 1961 May;107:135–138. doi: 10.3181/00379727-107-26558. [DOI] [PubMed] [Google Scholar]
  6. COSSEL L. [Electron microscopic studies on the liver sinusoids in viral hepatitis]. Klin Wochenschr. 1959 Dec 15;37:1263–1278. doi: 10.1007/BF01488544. [DOI] [PubMed] [Google Scholar]
  7. KUBELKA V., SLAVIK K., SOUSEK O. Ein Beitrag zum Studium der Hepatitis infectiosa. Zentralbl Bakteriol Orig. 1958 Jun;171(6-7):401–412. [PubMed] [Google Scholar]
  8. LIEBHABER H., KRUGMAN S., GILES J. P., MCGREGOR D. M. RECOVERY OF CYTOPATHIC AGENTS FROM PATIENTS WITH INFECTIOUS HEPATITIS: ISOLATION AND PROPAGATION IN CULTURES OF HUMAN DIPLOID LUNG FIBROBLASTS (WI-38). Virology. 1964 Sep;24:109–113. doi: 10.1016/0042-6822(64)90155-2. [DOI] [PubMed] [Google Scholar]
  9. MCCOLLUM R. W. The size of serum hepatitis virus. Proc Soc Exp Biol Med. 1952 Oct;81(1):157–160. doi: 10.3181/00379727-81-19809. [DOI] [PubMed] [Google Scholar]
  10. MCLEAN I. W., Jr CLINICAL SIGNIFICANCE OF RECENT INVESTIGATIONS OF HEPATITIS VIRUSES. Postgrad Med. 1964 May;35:481–487. doi: 10.1080/00325481.1964.11695115. [DOI] [PubMed] [Google Scholar]
  11. O'MALLEY J. P., MEYER H. M., Jr, SMADEL J. E. Antibody in hepatitis patients against a newly isolated virus. Proc Soc Exp Biol Med. 1961 Oct;108:200–205. doi: 10.3181/00379727-108-26891. [DOI] [PubMed] [Google Scholar]
  12. RIGHTSEL W. A., KELTSCH R. A., TAYLOR A. R., BOGGS J. D., McLEAN I. W., Jr, CAPPS R. B., WEISS C. F. Status report on tissue-culture cultivated hepatitis virus. I. Virology laboratory studies. II. Clinical trials. JAMA. 1961 Sep 9;177:671–682. doi: 10.1001/jama.1961.03040360007002. [DOI] [PubMed] [Google Scholar]
  13. RIGHTSEL W. A., KELTSCH R. A., TEKUSHAN F. M., MCLEAN I. W., Jr Tissue-culture cultivation of cytopathogenic agents from patients with clinical hepatitis. Science. 1956 Aug 3;124(3214):226–228. doi: 10.1126/science.124.3214.226. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES