Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1967 Jan;20(1):52–55. doi: 10.1136/jcp.20.1.52

Blood lipid levels, thyroid status, and glucose tolerance in progressive partial lipodystrophy

B M Rifkind 1, J A Boyle 1, Morna Gale 1
PMCID: PMC473420  PMID: 6016888

Abstract

Eight women with uncomplicated progressive partial lipodystrophy and two with progressive lipodystrophy and diabetes mellitus were studied. Plasma triglyceride levels were significantly elevated in the subjects with uncomplicated lipodystrophy; serum cholesterol, phospholipid, and plasma free fatty acid levels were normal. Paper electrophoresis showed increases in serum pre-beta lipoprotein and chylomicra. Thyroid function, as measured by radioiodine and stable iodine studies, was normal. Some subjects had a raised basal metabolic rate. Intravenous glucose tolerance was normal in patients with the uncomplicated disease.

Full text

PDF

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ARMSTRONG D. T., STEELE R., ALTSZULER N., DUNN A., BISHOP J. S., DE BODO R. C. Regulation of plasma free fatty acid turnover. Am J Physiol. 1961 Jul;201:9–15. doi: 10.1152/ajplegacy.1961.201.1.9. [DOI] [PubMed] [Google Scholar]
  2. BARTLETT G. R. Human red cell glycolytic intermediates. J Biol Chem. 1959 Mar;234(3):449–458. [PubMed] [Google Scholar]
  3. BERSON S. A., YALOW R. S., SORRENTINO J., ROSWIT B. The determination of thyroidal and renal plasma I131 clearance rates as a routine diagnostic test of thyroid dysfunction. J Clin Invest. 1952 Feb;31(2):141–158. doi: 10.1172/JCI102585. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. BOYLE J. A., SLOSS A., MACDONALD E., GRAY M. A COMPARISON OF TWO METHODS OF ESTIMATION OF PLASMA INORGANIC IODINE IN ETHYROID, HYPERTHYROID AND GOITROUS PATIENTS. J Clin Endocrinol Metab. 1965 Aug;25:1035–1042. doi: 10.1210/jcem-25-8-1035. [DOI] [PubMed] [Google Scholar]
  5. CARLSON L. A. Serum lipids in normal men. Acta Med Scand. 1960 Aug 10;167:377–397. doi: 10.1111/j.0954-6820.1960.tb03560.x. [DOI] [PubMed] [Google Scholar]
  6. DOLE V. P. A relation between non-esterified fatty acids in plasma and the metabolism of glucose. J Clin Invest. 1956 Feb;35(2):150–154. doi: 10.1172/JCI103259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. FARRELL L. P., RICHMOND M. H. A rapid method for the estimation of serum protein-bound iodine. Clin Chim Acta. 1961 Sep;6:620–623. doi: 10.1016/0009-8981(61)90104-8. [DOI] [PubMed] [Google Scholar]
  8. KOUTRAS D. A., ALEXANDER W. D., BUCHANAN W. W., CROOKS J., WAYNE E. J. Stable iodine metabolism in non-toxic goitre. Lancet. 1960 Oct 8;2(7154):784–787. doi: 10.1016/s0140-6736(60)91855-9. [DOI] [PubMed] [Google Scholar]
  9. LEES R. S., HATCH F. T. Sharper separation of lipoprotein species by paper electrophoresis in albumin-containing buffer. J Lab Clin Med. 1963 Mar;61:518–528. [PubMed] [Google Scholar]
  10. LUNDBAEK K. Intravenous glucose tolerance as a tool in definition and diagnosis of diabetes mellitus. Br Med J. 1962 Jun 2;1(5291):1507–1513. doi: 10.1136/bmj.1.5291.1507. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. MURRAY I. P., MCGIRR E. M. Radioactive iodine studies in the diagnosis of Hashimoto's thyroiditis. Br Med J. 1960 Mar 19;1(5176):838–841. doi: 10.1136/bmj.1.5176.838. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. MURRAY I. Lipodystrophy. Br Med J. 1952 Dec 6;2(4796):1236–1239. doi: 10.1136/bmj.2.4796.1236. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. NESTEL P. J. RELATIONSHIP BETWEEN PLASMA TRIGLYCERIDES AND REMOVAL OF CHYLOMICRONS. J Clin Invest. 1964 May;43:943–949. doi: 10.1172/JCI104980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. POLEY J. R., STICKLER G. B. PROGRESSIVE LIPODYSTROPHY. A CLINICAL STUDY OF 50 PATIENTS. Am J Dis Child. 1963 Oct;106:356–363. [PubMed] [Google Scholar]
  15. SEIP M., TRYGSTAD O. GENERALIZED LIPODYSTROPHY. Arch Dis Child. 1963 Oct;38:447–453. doi: 10.1136/adc.38.201.447. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. SENIOR B., GELLIS S. S. THE SYNDROMES OF TOTAL LIPODYSTROPHY AND OF PARTIAL LIPODYSTROPHY. Pediatrics. 1964 Apr;33:593–612. [PubMed] [Google Scholar]
  17. Steinberg D. Fatty acid mobilization--mechanisms of regulation and metabolic consequences. Biochem Soc Symp. 1963;24:111–143. [PubMed] [Google Scholar]
  18. VAN HANDEL E., ZILVERSMIT D. B. Micromethod for the direct determination of serum triglycerides. J Lab Clin Med. 1957 Jul;50(1):152–157. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES