Table 2. IC50 values (μM) of doxorubicin (DOX) and cisplatin (CIS) in arginine-rich media (ARM) and arginine-free media (AFM).
N° | Cells | DOX (IC50 ± SD) | CIS (IC50 ± SD) | ||
---|---|---|---|---|---|
ARM | AFM | ARM | AFM | ||
1. | HeLa | 1.66 ± 0.30* | 4.07 ± 0.26* | 77.36 ± 9.11* | 54.07 ± 12.25* |
2. | Caco-2 | 33.55 ± 4.93 | 34.91 ± 5.70 | 105.88 ± 14.66 | 96.38 ± 32.03 |
3. | MIA PaCa-2 | 14.60 ± 1.21 | 22.25 ± 3.35 | 72.01 ± 3.50 | 97.20 ± 20.34 |
4. | BxPC-3 | 5.00 ± 0.74* | 6.90 ± 0.53* | 126.42 ± 34.07* | 85.66 ± 3.81* |
5. | Hep G2 | 1.86 ± 0.38* | 4.68 ± 1.08* | 23.99 ± 2.75* | 14.87 ± 1.22* |
6. | SK-HEP-1 | 7.92 ± 2.43* | 11.09 ± 0.82* | 117.40 ± 15.72 | 77.89 ± 17.77 |
Note:
Data from three independent experiments (n = 3) are represented as mean ± SD. The asterisk indicates a significant difference (at P < 0.05 analyzed using t-Test) in the cytotoxicity of the chemotherapeutic drug in cancer cells treated with arginine rich media (ARM) compared with arginin free media (AFM).