Table 4. IC₅₀ values (μM) of cisplatin (CIS) alone and in combination with L-canavanine (L-CAV) (constant ratio).

N°	Cells	Drug alone				Combination of L-CAV and DOX
		L-CAV		CIS		Combination (L-CAV : CIS)	Molar ratio (L-CAV : CIS)	CIS (IC50 ± SD)	CI Value	Interaction
		(IC50 ± SD)	(IC70 ± SD)	(IC50 ± SD)	(IC30 ± SD)
						50 : 1	50 : 1	0.60 ± 0.13	0.1875	++++
1.	HeLa	216.9 ± 47.72	581.41 ± 106.99	54.07 ± 12.25	34.24 ± 8.82	IC50 : IC50	4.01 : 1	3.58 ± 0.39	0.1359	++++
						IC70 : IC30	16.98 : 1	1.29 ± 0.24	0.1275	++++
						100 : 1	100 : 1	1.89 ± 0.65	0.2200	++++
2.	Caco-2	589.60 ± 138.92	1867.27 ± 623.99	96.38 ± 32.03	46.18 ± 13.40	IC50 : IC50	6.11 : 1	4.79 ± 0.06	0.1195	++++
						IC70 : IC30	40.44 : 1	3.00 ± 0.83	0.2606	++++
						5 : 1	5 : 1	55.34 ± 2.73	0.8887	++
3.	MIA PaCa-2	865.50 ± 315.30	3515.56 ± 978.67	97.20 ± 20.34	41.70 ± 10.02	IC50 : IC50	9.40 : 1	56.36 ± 1.34	1.1970	−
						IC70 : IC30	84.31 : 1	3.87 ± 0.17	0.5018	+++
						10 : 1	10 : 1	57.68 ± 5.04	0.9041	+
4.	BxPC-3	2167 ± 282.84	3563.97 ± 345.07	85.66 ± 3.81	48.34 ± 5.44	IC50 : IC50	24.59 : 1	18.06 ± 2.09	0.4032	+++
						IC70 : IC30	73.72 : 1	6.79 ± 0.48	0.2394	++++
						10 : 1	10 : 1	11.16 ± 3.14	0.6425	+++
5.	Hep G2	640.90 ± 164.68	1202.75 ± 397.31	14.87 ± 1.22	7.42 ± 0.24	IC50 : IC50	43.10 : 1	8.01 ± 0.53	0.8749	+
						IC70 : IC30	162.09 : 1	2.02 ± 0.03	0.5949	+++
						100 : 1	100 : 1	4.28 ± 0.46	0.4181	+++
6.	SK-HEP-1	1179 ± 149.08	2018.37 ± 678.23	77.89 ± 17.77	51.38 ± 16.26	IC50 : IC50	15.14 : 1	13.72 ± 2.87	0.3070	+++
						IC70 : IC30	39.28 : 1	7.34 ± 0.27	0.2806	++++

Note:

Data from three independent experiments (n = 3) are represented as mean ± SD.