Abstract
Bilateral adrenalectomy produces a reduction in the alkaline phosphatase concentration in rat intestine, which is not prevented by the administration of saline, but is prevented by the administration of cortisone. The administration of A.C.T.H. to normal rats leads to a rise in intestinal alkaline phosphatase levels associated with a small increase in the weight of the adrenals, while the administration of hydrocortisone produces large increases in the enzyme, even with doses which cause significant hypoplasia of the adrenal glands.
The significance of these findings in relation to mechanisms of fat absorption and the treatment of steatorrhoea is discussed.
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Selected References
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- DICKIE N., ROBINSON M. I., TUBA J. The role of alkaline phosphatase in intestinal absorption. III. The effects of various fatty acids on levels of the enzyme in intestinal mucosa. Can J Biochem Physiol. 1955 Jan;33(1):83–88. [PubMed] [Google Scholar]
- HEBERT S. Les phosphatases alcalines de l'intestin; étude histochimique expérimentale. Arch Biol (Liege) 1950;61(2):235–288. [PubMed] [Google Scholar]
- KIND P. R., KING E. J. Estimation of plasma phosphatase by determination of hydrolysed phenol with amino-antipyrine. J Clin Pathol. 1954 Nov;7(4):322–326. doi: 10.1136/jcp.7.4.322. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MARSH W. H., FINGERHUT B., KIRSCH E. Adaptation of an alkaline phosphatase method for automatic colorimetric analysis. Clin Chem. 1959 Apr;5(2):119–126. [PubMed] [Google Scholar]
- MORTON R. K. The purification of aklaline phosphatases of animal tissues. Biochem J. 1954 Aug;57(4):595–603. doi: 10.1042/bj0570595. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TUBA J., DICKIE N. The role of alkaline phosphatase in intestinal absorption. II. The effects of various carbohydrates on levels of the enzyme in intestinal mucosa. Can J Biochem Physiol. 1954 Nov;32(6):621–624. [PubMed] [Google Scholar]
- Watson W. C., Murray E. Fat digestion and absorption in the adrenalectomized rat. J Lipid Res. 1966 Mar;7(2):236–241. [PubMed] [Google Scholar]