Abstract
One of the current methods used for measuring natural fibrinolytic activity in blood involves dilution of the blood with phosphate buffer. An adaptation of this method using a solution of sodium acetate as diluent is described. Evidence is given to show that dilute blood clots lyse not only because of the dissociation of an antiplasmin-plasmin complex, but also by virtue of a reduction of the intrinsic chloride ion concentration.
Full text
PDF




Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- CHAKRABARTI R., FEARNLEY G. R. The 'fibrinolytic potential' as a simple measure of spontaneous fibrinolysis. J Clin Pathol. 1962 May;15:228–230. doi: 10.1136/jcp.15.3.228. [DOI] [PMC free article] [PubMed] [Google Scholar]
- DALBY A., MERTZ E. T. Effect of chloride and other ions on the activation of bovine plasminogen (profibrinolysin). Am J Physiol. 1957 Dec;191(3):505–511. doi: 10.1152/ajplegacy.1957.191.3.505. [DOI] [PubMed] [Google Scholar]
- FEARNLEY G. R., BALMFORTH G., FEARNLEY E. Evidence of a diurnal fibrinolytic rhythm; with a simple method of measuring natural fibrinolysis. Clin Sci. 1957 Nov;16(4):645–650. [PubMed] [Google Scholar]
- FEARNLEY G. R., REVILL R., TWEED J. M. Observations on the inactivation of fibrinolytic activity in shed blood. Clin Sci. 1952 Aug;11(3):309–314. [PubMed] [Google Scholar]
- Gallimore M. J., Nulkar M. V., Shaw J. T. A comparative study of the inhibitors of fibrinolysis in human, dog and rabbit blood. Thromb Diath Haemorrh. 1965 Sep 1;14(1-2):145–158. [PubMed] [Google Scholar]
