Abstract
A haemorrhagic diathesis is described in infants; this is preceded and accompanied by constitutional symptoms such as fever, diarrhoea, vomiting, anorexia, and pallor. These children had a severe coagulation abnormality, due to deficiency of vitamin-K-dependent coagulation factors, and it was corrected by administration of vitamin K. No conclusion could be drawn as to the aetiology of this condition but some possible causes are discussed.
Full text
PDF




Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BIGGS R. Some observations on the blood of patients with factor-VII deficiency. Br J Haematol. 1956 Oct;2(4):412–420. doi: 10.1111/j.1365-2141.1956.tb06715.x. [DOI] [PubMed] [Google Scholar]
- DEARING W. H., MANN F. D., NEEDHAM G. M. The prothrombin and the intestinal bacteria of patients being prepared with terramycin for surgery of the bowel. Proc Staff Meet Mayo Clin. 1952 Feb 13;27(4):84–87. [PubMed] [Google Scholar]
- DOUGLAS A. S., MAIR K. The Christmas factor deficiency in coumarin therapy. Clin Sci. 1958 Aug;17(3):445–455. [PubMed] [Google Scholar]
- DOUGLAS A. S. Some observations on the coagulation defect in vitamin K deficiency. J Clin Pathol. 1958 May;11(3):261–264. doi: 10.1136/jcp.11.3.261. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Herfort R. A., Standard S. Oral Streptomycin in Surgery of the Large Bowel: The Production of Secondary Hypoprothrombinemia. Ann Surg. 1948 Nov;128(5):987–992. doi: 10.1097/00000658-194811000-00014. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Jaques L. B. The reaction of heparin with proteins and complex bases. Biochem J. 1943 Jul;37(2):189–195. doi: 10.1042/bj0370189. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MERSKEY C., HANSEN J. D. Blood coagulation defects in kwashiorkor and infantile gastroenteritis. Br J Haematol. 1957 Jan;3(1):39–49. doi: 10.1111/j.1365-2141.1957.tb05769.x. [DOI] [PubMed] [Google Scholar]
- NAEYE R. L. Plasma thromboplastin component: influence of coumarin compounds and vitamin K on its activity in serum. Proc Soc Exp Biol Med. 1956 Jan;91(1):101–104. doi: 10.3181/00379727-91-22180. [DOI] [PubMed] [Google Scholar]
- NEWCOMB T., MATTER M., CONROY L., DEMARSH Q. B., FINCH C. A. Congenital hemorrhagic diathesis of the prothrombin complex. Am J Med. 1956 May;20(5):798–805. doi: 10.1016/0002-9343(56)90163-2. [DOI] [PubMed] [Google Scholar]
- SINGER K., MOND E., HYMAN J., LEVY R. C. Circulating anticoagulants in hemophilia and in hemophilia-like disease. Blood. 1950 Dec;5(12):1135–1149. [PubMed] [Google Scholar]
- Unger P. N., Shapiro S., Schwalb S. THE PROTHROMBIN RESPONSE TO THE PARENTERAL ADMINISTRATION OF LARGE DOSES OF VITAMIN K IN SUBJECTS WITH NORMAL LIVER FUNCTION AND IN CASES OF LIVER DISEASE: A STANDARDIZED TEST FOR THE ESTIMATION OF HEPATIC FUNCTION. J Clin Invest. 1948 Jan;27(1):39–47. doi: 10.1172/JCI101922. [DOI] [PMC free article] [PubMed] [Google Scholar]


