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. 2015 Sep;1(1):3–17. doi: 10.18383/j.tom.2015.00136

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© 2015 The Authors. Published by Grapho Publications, LLC

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by/4.0/).

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Figure 7. — QSM of early-stage PD illustrates the regions of deep brain nuclei (A, B): the head of caudate nucleus (CN); putamen (PUT); globus pallidus (GP); substantia nigra (SN); and red nucleus (RN). (C) Scatter plots and regression lines show the significant relationship between susceptibility values in bilateral SN and clinical measures in early-stage PD. Correlations are partialed for age. The susceptibility value of ipsilateral SN is positively correlated with disease duration (top left: r = 0.391, P = .0094) and UPDRS III score (bottom left: r = 0.386, P = .0105) in PD. The susceptibility value in SN contralateral to the most affected side in PD patients is positively correlated with disease duration (top right: r = 0.347, P = .0226) and UPDRS III score (bottom right: r = 0.368, P = .0152). Reproduced with permission from He et al. (76).